2023-2024 Publications & International Presentations

Questions, contact BRITL Program Director Kore Kai Liow, MD, [email protected]

Info:   Brain Research, Innovation, Translation Labs.    Summer Internship Opportunities

2023-2024 Full Length PUBMED Indexed Publications

Meropol SB, Norris CJ, Frontera JA, Adeagbo A, Troxel AB; COVID-19 Neuro Databank/Biobank Consortium. The National Institutes of Health COVID-19 Neuro Databank/Biobank: Creation and Evolution. Neuroepidemiology. 2024 Jun 26:1-13. doi: 10.1159/000539830. Epub ahead of print. PMID: 38934169.

Tiffany Cava Morden F, Xin Liang B, Nguyen L, Carrazana E, Ghaffari-Rafi A, Kai Liow KPartial Rhombencephalosynapsis Presenting in an Adult with Cerebello-Trigeminal-Dermal Dysplasia. Epilepsy Behav Rep. 2024;27:100688. doi: 10.1016/j.ebr.2024.100688. eCollection 2024. PubMed PMID: 39050404; PubMed Central PMCID: PMC11268192.

Liow K, Wheless JW, Cook DF, Rabinowicz AL, Carrazana E. Diazepam Nasal Spray Administration Is Effective to Control Seizure Clusters Irrespective Of Time Of Day. Front Neurol. 2024 May 24;15:1335421. doi: 10.3389/fneur.2024.1335421. PMID: 38854958; PMCID: PMC11157958.

Weldon EJ, Nakamura RW, Van T, Goo C, Lee AY, Jahansooz JR, Carrazana E, Liow KKExercise and Recovery Following Mild-to-Moderate Traumatic Brain Injury in the Community Setting. Cureus. 2024 Feb;16(2):e53459. 

doi: 10.7759/cureus.53459. eCollection 2024 Feb. PubMed PMID: 38435185; PubMed Central PMCID: PMC10909398.

Goo C, Morden F, Wong K, Aquino S, Kawamura J, Rubel V, Masca S, Gorenflo R, Carrazana E, Liow K. Familiarity and Perceptions of Aducanumab in Caregivers of Hawaii Alzheimer’s Disease Patients: Results of a Telephone Survey. Cureus. 2023 Dec 5;15(12):e50001. doi: 10.7759/cureus.50001. PMID: 38186481; PMCID: PMC10767469.

Kim NN, Tan C, Ma E, Kutlu S, Carrazana E, Vimala V, Viereck J, Liow K. Abnormal Temporal Slowing on EEG Findings in Preclinical Alzheimer’s Disease Patients With the ApoE4 Allele: A Pilot Study. Cureus. 2023 Oct;15(10):e47852. doi: 10.7759/cureus.47852. eCollection 2023 Oct. PubMed PMID: 38021568; PubMed Central PMCID: PMC10679961.

Lee AY, Jahansooz JR, Guittu D, Suzuki R, Pak L, Ishikawa KM, Goo C, Chen JJ, Carrazana E, Viereck J, Liow KK. Barriers to Alzheimer Disease Clinical Trial Participation in a Minority Population. Cogn Behav Neurol. 2024 Mar 1;37(1):40-47. doi: 10.1097/WNN.0000000000000359. PubMed PMID: 37878413; PubMed Central PMCID: PMC10948321

Siriwardhana C, Carrazana E, Liow K, Chen JJ. Racial/Ethnic Disparities in the Alzheimer’s Disease Link with Cardio and Cerebrovascular Diseases, Based on Hawaii Medicare Data. J Alzheimers Dis Rep. 2023;7(1):1103-1120. doi: 10.3233/ADR-230003. eCollection 2023. PubMed PMID: 37849625; PubMed Central PMCID: PMC10578323.

French J, Biton V, Dave H, Detyniecki K, Gelfand MA, Gong H, Liow K, O’Brien TJ, Sadek A, DiVentura B, Reich B, Isojarvi J. A randomized phase 2b efficacy study in patients with seizure episodes with a predictable pattern using Staccato® alprazolam for rapid seizure termination. Epilepsia. 2023 Feb;64(2):374-385. doi: 10.1111/epi.17441. Epub 2022 Dec 7. PubMed PMID: 36268811; PubMed Central PMCID: PMC10107237.

Weldon EJ 4th, Hong B, Hayashi J, Goo C, Carrazana E, Viereck J, Liow KMechanisms and Severity of Exercise Intolerance Following COVID-19 and Similar Viral Infections: A Comparative Review. Cureus. 2023 May;15(5):e39722. doi: 10.7759/cureus.39722. eCollection 2023 May. Review. PubMed PMID: 37398713; PubMed Central PMCID: PMC10310058.

Howard JF Jr, Bresch S, Genge A, Hewamadduma C, Hinton J, Hussain Y, Juntas-Morales R, Kaminski HJ, Maniaol A, Mantegazza R, Masuda M, Sivakumar K, Śmiłowski M, Utsugisawa K, Vu T, Weiss MD, Zajda M, Boroojerdi B, Brock M, de la Borderie G, Duda PW, Lowcock R, Vanderkelen M, Leite MI. Safety and efficacy of zilucoplan in patients with generalised myasthenia gravis (RAISE): a randomised, double-blind, placebo-controlled, phase 3 study. Lancet Neurol. 2023 May;22(5):395-406. doi: 10.1016/S1474-4422(23)00080-7. PubMed PMID: 37059508.

Liang BX, Carrazana E, Viereck J, Liow KKThe Gomez-Lopez-Hernandez Syndrome: The Contribution of 2 Hispanic Giants of Pediatric Neurology. J Child Neurol. 2023 Apr;38(5):347-350. doi: 10.1177/08830738231176057. Epub 2023 May 18. PubMed PMID: 37203136.

Bril V, Drużdż A, Grosskreutz J, Habib AA, Mantegazza R, Sacconi S, Utsugisawa K, Vissing J, Vu T, Boehnlein M, Bozorg A, Gayfieva M, Greve B, Woltering F, Kaminski HJ. Safety and efficacy of rozanolixizumab in patients with generalised myasthenia gravis (MycarinG): a randomised, double-blind, placebo-controlled, adaptive phase 3 study. Lancet Neurol. 2023 May;22(5):383-394. doi: 10.1016/S1474-4422(23)00077-7. PubMed PMID: 37059507.

Buffenstein I, Kaneakua B, Taylor E, Matsunaga M, Choi SY, Carrazana E, Viereck J, Liow KK, Ghaffari-Rafi A. Demographic recruitment bias of adults in United States randomized clinical trials by disease categories between 2008 to 2019: a systematic review and meta-analysis. Sci Rep. 2023 Jan 2;13(1):42. doi: 10.1038/s41598-022-23664-1. PubMed PMID: 36593228; PubMed Central PMCID: PMC9807581.

Fang C, Hernandez P, Liow K, Damiano E, Zetterberg H, Blennow K, Feng D, Chen M, Maccecchini M. Buntanetap, a Novel Translational Inhibitor of Multiple Neurotoxic Proteins, Proves to Be Safe and Promising in Both Alzheimer’s and Parkinson’s Patients. J Prev Alzheimers Dis. 2023;10(1):25-33. doi: 10.14283/jpad.2022.84. PubMed PMID: 36641607.

2023-2024 National and International Presentations led by BRITL student scholars

The Safety and Effectiveness of Dual Calcitonin Gene-Related Peptide (CGRP) Therapies for Migraine Treatment: A Focus on Small Molecule Antagonist and Ligand Monoclonal Combinations. Ho Hyun Lee, Anita J Cheung,, Julia R Jahansooz, Edward J Weldon, Anson Y Lee, Kyle M Ishikawa, Nicole Little, Enrique Carrazana, , Kore K Liow. Migraine Trust International Symposium September, 2024. London, England.

Pharmacokinetics and tolerability of single-dose Staccato® alprazolam in adolescents with epilepsy and population PK analysis to support dose selection in adolescents

Klein, Pave; Aungaroon, Gewalin; Biton, Victor; Liow, Kore Kai; Phillips, Steven; Wychowski, Thomas6; Sadek, Ahmed; Elshoff, Jan-Peer; Roebling, Robert; King, Aliceson; Ford, Andrea10; Rospo, Chiara C; Schoemaker, Rik; Chanteux, Hugues. 15th European Epilepsy Congress (EEC), Rome, Italy. September, 2024

Cheung AJ, Nishimura  MK, Miyaki KJ, Stephens TA, Weldon EJ, Jahansooz JR, Lee AY, Matsunaga M, Chang JC, Carrazana E, Viereck V, Liow KK. Exploring Radiculopathy in Underserved Communities: A Focus on AANHPI Populations and Risk Factors. Neurology 102 (17_supplement_1), 5405 American Academy of Neurology 2024 Annual Meeting, April 15, 2024 Denver, CO

The Safety and Efficacy of Dual Calcitonin Gene-Related Peptide Therapies for Migraine Treatment. Ho Hyun Lee, Reyn Yoshioka, Man Ian Woo, Lana Liquard, Julia Jahansooz, Edward Weldon, Anson Lee, Kyle Ishikawa, Nicole Little, Enrique Carrazana, Jason Viereck, Kore Liow. Neurology 102 (17_supplement_1), 3820 American Academy Neurology Meeting, 2024 April. 

Pharmacokinetics and Tolerability of Single-dose Staccato® Alprazolam in Adolescents with Epilepsy and Population PK Analysis to Support Dose Selection in Adolescents. American Academy Neurology Meeting, 2024 April.

Tobacco, Marijuana, and Antidepressant Use Prior to Concussion Are Associated with Increased Depression Risk in Post-concussive Syndrome Patients. Eli Snyder, Ryan Nakamura, Miriya Ogawa, Kaylin Bersamin, Edward Weldon, Julia Jahansooz, Anson Lee, Kyle Ishikawa, Janette Abramowitz, Enrique Carrazana, Jason Viereck, Kore Liow. Neurology 102 (17_supplement_1), 3832. American Academy of Neurology 2024 Annual Meeting; April 14, 2024; Denver, CO.

VNS in Lennox-Gastaut Syndrome: Real-world Experience from CORE-VNS (P3-1.014)

Paul Lyons, James Wheless, Ryan Verner, Jose Ferreira, Kore Liow, James Valeriano, Gholam K. Motamedi, Neurology 102 (17_supplement_1), 6902. American Academy Neurology Meeting, 2024 April.

Factors Associated with Depression Risk in Post-Concussive Syndrome Patients in Hawaii. 2024.  Eli Snyder, Ryan Nakamura, Miriya Ogawa, Kaylin Bersamin, Edward Weldon, Julia Jahansooz, Anson Lee, Kyle Ishikawa, Janette Abramowitz, Enrique Carrazana, Jason Viereck,, Kore Liow. American Neuropsychiatric Association 34th Annual Meeting; March 8, 2024; Houston, TX

Progression of Parkinson’s Disease in Asian and Native Hawaiian and Pacific Islander Populations. Borrello K, Nakahira S, Fontana P, Giuttu D, Hunter C, Jahansooz JR, Weldon EJ, Lee AY, Roman M, Ahn HJ, Viereck J, Carrazana E, Liow K. Poster presentation at International Conference on Alzheimer’s and Parkinson’s Diseases and related neurological disorders (ADPD), Lisbon, Portugal. March 2024.

VNS in Lennox-Gastaut Syndrome: Real World Experience from CORE-VNS. Paul Lyons1, James Wheless2, Ryan Verner3, Jose Ferreira4, Kore Liow5, James Valeriano6, and Gholam Motamedi7, on behalf of the CORE-VNS Registry Group. American Epilepsy Society Meeting, 2023 December.

Pharmacokinetics and Tolerability of Single-dose Staccato® Alprazolam in Adolescents with Epilepsy and Population PK Analysis to Support Dose Selection in Adolescents. American Epilepsy Society Meeting, 2023 December.

Cheung AJ, Nishimura  MK, Miyaki KJ, Stephens, TA, Weldon EJ, Jahansooz JR, Lee AY, Matsunaga M, Chang JC, Carrazana E, Viereck V, Liow, KK. Exploring Radiculopathy in Underserved Communities: A Focus on AANHPI Populations and Risk Factors. The 3rd International Conference on Controversies in Neuropathic Pain, November 20, 2023, Brussels, Belgium (Oral Platform Presentation)

EEG slowing and CSF amyloid status: Implications for Alzheimer’s disease detection and progression. N Kim, S Nakahira, A Lee, E Hagen, E Carrazana, J Viereck, K Liow

Journal of the Neurological Sciences 455. World Congress of Neurology, Montreal, CANADA, 2023 October

Investigating Young Atypical Stroke Risk Factors and Etiologies in Native Hawaiian and Pacific Islander Populations. D-Dre Wright, Michelle Lu, Anson Y. Lee, Edward J. Weldon, Julia R. Jahansooz, Kyle M. Ishikawa, Enrique Carrazana, Jason Viereck, Kore K. Liow. Journal of the Neurological Sciences 455. World Congress of Neurology, Montreal, CANADA, 2023 October. 

Chronic Migraine and Comorbidity Characterization: A Focus on Native Hawaiians and Other Pacific Islanders.  Anita Cheung MPH Michelle Lu, Anson Y. Lee, Julia R. Jahansooz MS, Edward J. Weldon, Meliza Roman, Enrique Carrazana, Jason Viereck, Kore Kai. Liow, Journal of the Neurological Sciences, Volume 455, 121626 . 2023 World Congress of Neurology, Montreal, CANADA, 2023 October.

Impact of Return-to-Exercise on Traumatic Brain Injury Recovery in a Community Setting.  Edward Weldon, Ryan Nakamura, Tracy Van, Ana Nakamura, Chancen Law, Connor Goo, Meliza Roman, Enrique Carrazana, Jason Viereck, Kore Liow. American Academy of Neurology. Neurology 100 (17_supplement_2), 2895.  2023 American Academy Neurology Annual Meeting, April 2023, Boston, MA

Investigating the Prevalence of Psychiatric Disorders in Multiple Sclerosis with Autoimmune Comorbidities (P5-3.008). Shin Chang, Plyfaa Suwanamalik-Murphy, Jenna Okazaki, Donovan Roy, Masako Matsunaga, Connor Goo, Enrique Carrazana, Jason Viereck, Kore Liow. Neurology 100 (17_supplement_2), 2371. 2023 American Academy Neurology Annual Meeting, April 2023, Boston, MA

Different Experiences in Chronic Migraine Etiology, Treatment and Comorbidities of Hawaii’s Ethnic Groups (P14-12.006).  Michelle Lu, Kacey Yamane, Dane Keahi, Michael Tong, Connor Goo, Devashri Prabhudesai, John Chen, Vimala Sravanthi Vajjala, Enrique Carrazana, Jason Viereck, Kore Liow. Neurology 100 (17_supplement_2), 2566.  2023 American Academy Neurology Annual Meeting, April 2023, Boston, MA

The Gomez-Lopez-Hernandez Syndrome: the contribution of two Hispanic giants of Pediatric Neurology.(P4-3.004). BX Liang, J Viereck, KK Liow, E Carrazana. Neurology 100 (17_supplement_2), 2782. 2023 American Academy Neurology Annual Meeting, April 2023, Boston, MA

Barriers To Alzheimer’s Disease Clinical Trial Participation in Hawaii’s Minority-Majority Population.  Anson Y Lee, Julia R Jahansooz, Darrell Guittu, Rexton Suzuki, Lauren Pak, Kyle M Ishikawa, Connor Goo, John J Chen, Enrique Carrazana , Jason Viereck, Kore K Liow.   2023 ADPD Advances in Science & Therapy. March 2023, Gothenburg, Sweden.

Impact of Mild Cognitive Impairment On One’s Fall Risk And Risk For More Frequent And Severe Traumatic Brain Injuries. Chloe Delos Reyes, Ryan Nakamura, Anson Lee, Edward Weldon, Julia Jahansooz, Kyle Ishikawa, Enrique Carrazana, Jason Viereck, Kore Liow. Journal of the Neurological Sciences, Volume 455, 121903. 2023 World Congress of Neurology, Montreal, CANADA

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