Publications
Recent Publication
Student or Resident Led PubMed Peer Reviewed Publications
Cogn Behav Neurol. 2021 Sep 2;34(3):200-206. doi: 10.1097/WNN.0000000000000279.
PubMed PMID: 34473671.
Morden FTC, Tan C, Carrazana E, Viereck J, Liow KK, Ghaffari-Rafi A. Characterizing
idiopathic intracranial hypertension socioeconomic disparities and clinical risk factors: A
retrospective case-control study. Clin Neurol Neurosurg. 2021 Aug 14;208:106894
PMID: 34455402.
PMID: 34409517 https://link.springer.com/article/10.1007%2Fs10072-021-05547-x
Ko AWK, Ghaffari-Rafi A, Chan A, Harris WB, Imasa A, Liow KK, Viereck J. A Case Report of Antibiotic-Induced Aseptic Meningitis in Psoriasis. Hawaii J Health Soc Welf. 2021 Jun;80(6):129-133.
PubMed PMID: 34195619; PubMed Central PMCID: PMC8237324.Online PDF Access
Early impact of the COVID-19 pandemic on outpatient Migraine care in Hawaii: Results of a quality improvement survey.
Smith M, Nakamoto M, Crocker J, Tiffany Morden F, Liu K, Ma E, Chong A, Van N, Vajjala V, Carrazana E, Viereck J, Liow K.
Headache. 2020 Dec 14;. doi: 10.1111/head.14030. PubMed PMID: 33316097
Epilepsy in the time of COVID-19.
Nakamoto M, Carrazana E, Viereck J, Liow K.
Acta Neurol Scand. 2020 Oct 11;. doi: 10.1111/ane.13360. PubMed PMID: 33043445; PubMed Central PMCID: PMC7675556
Apr 28. PubMed PMID: 32371292.
Medical School Hotline: Hawai’i Pacific Neuroscience Summer Internship Program.
Smith M, Wicknick A, Liow KK.
Hawaii J Health Soc Welf. 2020 Mar 1;79(3):82-85. PubMed PMID: 32190840; PubMed Central PMCID: PMC7061031
Presentation of psychogenic nonepileptic seizures in Hawaii’s ethnoracially diverse.
Ho R, Ocol J, Lu C, Dolim S, Yang M, Carrazana E, Liow KK.
Epilepsy Behav. 2019 Jul;96:150-154. doi: 10.1016/j.yebeh.2019.04.024. Epub 2019 May 28. PubMed PMID: 31146179.
Zika Virus: Relevance to the State of Hawai’i.
Lew WJ, Tsai WY, Balaraman V, Liow KK, Tyson J, Wang WK.
Hawaii J Med Public Health. 2019 Apr;78(4):123-127. PubMed PMID: 30972234; PubMed Central PMCID: PMC6452016.
Inappropriate Laughter and Behaviours: How, What, and Why? Case of an Adult with Undiagnosed Gelastic Seizure with Hypothalamic Hamartoma.
Beckwith NL, Khil JC, Teng J, Liow KK, Smith A, Luna J.
Hawaii J Med Public Health. 2018 Dec;77(12):319-324. PubMed PMID: 30533284; PubMed Central PMCID: PMC6277842.
Student or Resident Led National or International Abstract/Presentations
Evaluating Whether EEG could Predict Alzheimer’s Disease Onset in Preclinical Patients with the ApoE4 Allele Ma E, Kutlu S, Kim N, Mitchell C, Vajjala V, Carrazana E, Viereck J, Liow K 2021 AAIC (Alzheimer’s Association International Conference), Denver, CO, Wednesday July 26th
Systematic Review of Recruitment Bias in U.S. Phase 2 and 3 Randomized Clinical Trials of Cancer & Chemotherapy in Adults: 2008-2019. Buffenstein, I, Taylor E, Kāneakua, B, Matsunaga, M., Choi SY, Carrazana E, Liow, K, Viereck,J, Ghaffari-Rafi A. International Cancer Education Conference, Virtual, October 12-16, 2021
Demographic Bias in Opioid Use Disorder Clinical Trials. Buffenstein, I, Taylor E, Kāneakua, B, Carrazana E, Liow, K, Viereck,J, Ghaffari-Rafi A. American Medical Association Research Challenge. Virtual Conference, December 2021
Psychiatric, and Biological Risk Factors in Psychogenic Nonepileptic Seizures. Gorenflo R, Ho R, Viereck J, Mitchell C, Carrazana E, Liow KK, Ghaffari-Rafi A, Identifying Socioeconomic, 25th World Congress of Neurology. Annual Scientific Meeting, Rome, Italy. October 3-7, 2021
Comparing Epilepsy to Psychogenic Non-Epileptic Seizures, Identification of Risk Factors: A Retrospective Case-Control Study. Ho R, Gorenflo R, Viereck J, Mitchell C, Carrazana E, Liow KK, Ghaffari-Rafi. 25th World Congress of Neurology. Annual Scientific Meeting, Rome, Italy. October 3-7, 2021
Sociodemographic Disparities and Risk Factors in Diagnosing Idiopathic Intracranial Hypertension: A Retrospective Case-Control Study.
Frances Morden Charissa Tan, Enrique Carrazana, Jason Viereck, Kore Kai Liow, Arash Ghaffari-Rafi.
J of Neurosurgery Supplements 2021
Assessing U.S. Demographic Recruitment Bias in 21st Century Neurosurgery Clinical Trials.
Taylor E, Buffenstein I, Kāneakua B, Ghaffari-Rafi A, Viereck J, Carrazana E, Liow K.
J of Neurosurgery Supplements 2021
Effectiveness of Dual Migraine therapy with CGRP Antagonists and OnabotulinumtoxinA Injections: Experience from a Single Migraine Center in Hawaii.
Lee J, Liang Y, Newman B, Tamanaha R, Toni T, Carrazana E, Vajjala V, Viereck J, Liow K.
Cephalgia 40 (IS), 2020 Pg. 104
COVID-19 Pandemic Effect on Epilepsy Outpatient Care at a Regional Referral Center in Hawaii.
Nakamoto M, Smith M, Crocker J, Morden F, Liu K, Ma E, Chong A, Van N, Mitchell C, Zhu E, Dang N, Carrazana E, Viereck J, Liow K.
Epilepsia Supplements December, 2020
Biopsychological predictors in patients with psychogenic non-epileptic seizures from a comprehensive epilepsy center in Hawai’i
C Lu, R Ho, J Ocol, M Yang, E Carrazana, K Liow,
Epilepsia Supplements December, 2019
Use of Cannabinoids in Patients with Epilepsy from a Comprehensive Epilepsy Center in Hawaii. R
Ho, J Zhang, C Lu, B Fong, K Oura, A Shipman, H Hu, A Appana, G Slattery, E Carrazana , K Liow,
Epilepsia Supplements December, 2019
Presentation of PNES in Hawaii’s Ethnoculturally Diverse Patients
Ocol J, Ho R, Lu C, Dolim S, Yang M, Kaplan A, Wilson C, Lee E, Carrazana E. Liow K. 2018
American Epilepsy Society Meeting, Epilepsia 2018.
National or International Presentations
Sociodemographic Disparities and Risk Factors in Diagnosing Idiopathic Intracranial Hypertension: A Retrospective Case-Control Study.
Frances Morden, Charissa Tan, Enrique Carrazana, Jason Viereck, Kore Kai Liow, Arash Ghaffari-Rafi.
American Association of Neurological Surgeons, Annual Scietific Meeting, Orlando, FL, August 2021
Assessing U.S. Demographic Recruitment Bias in 21st Century Neurosurgery Clinical Trials. Taylor E, Buffenstein I, Kāneakua B, Ghaffari-Rafi A, Viereck J, Carrazana E, Liow K. American Association of Neurological Surgeons, Annual Scientific Meeting, Orlando, FL, August 2021
Factors that Affect the Employability of Patients with Epilepsy in Hawaii: A Look at Race, Comorbidities, and Marital Status.
Gorenflo R, Kimball L, Taeza B, Gan A, Viereck J, Carrazana E, Liow K.
American Academy of Neurology Annual Meeting, April 2021
Effectiveness of Dual Migraine therapy with CGRP Antagonists and OnabotulinumtoxinA Injections: Experience from a Single Migraine Center in Hawaii.
Lee J, Liang Y, Newman B, Tamanaha R, Toni T, Carrazana E, Vajjala V, Viereck J, Liow K. 2020 International Headache Society Annual Meeting
COVID-19 Pandemic Effect on Epilepsy Outpatient Care at a Regional Referral Center in Hawaii.
Nakamoto M, Smith M, Crocker J, Morden F, Liu K, Ma E, Chong A, Van N, Mitchell C, Zhu E, Dang N, Carrazana E, Viereck J, Liow K.
74th Annual Meeting of the American Epilepsy Society Meeting, Seattle, WA, Dec 2020.
Use of Cannabinoids in Patients with Epilepsy from a Comprehensive Epilepsy Center in Hawaii.
R Ho, J Zhang, C Lu, B Fong, K Oura, A Shipman, H Hu, A Appana, G Slattery, E Carrazana, K Liow,
American Epilepsy Society Annual Meeting, Baltimore, MD, Dec, 2019
Biopsychological predictors in patients with psychogenic non-epileptic seizures from a comprehensive epilepsy center in Hawai’i,
C Lu, R Ho, J Ocol, M Yang, E Carrazana, K Liow
American Epilepsy Society Annual Meeting, Baltimore, MD, Dec, 2019
Neuroscience Faculty Recent PubMed Peer Reviewed Publications
Wheless JW, Miller I, Hogan RE, Dlugos D, Biton V, Cascino GD, Sperling MR, Liow K, Vazquez B, Segal EB, Tarquinio D, Mauney W, Desai J, Rabinowicz AL, Carrazana E; DIAZ.001.05 Study Group. Final results from a Phase 3, long-term, open-label, repeat-dose safety study of diazepam nasal spray for seizure clusters in patients with epilepsy. Epilepsia. 2021 Aug 21. doi: 10.1111/epi.17041.
PMID: 34418086. https://onlinelibrary.wiley.com/doi/epdf/10.1111/epi.17041
Carrazana EJ.
Portrait of My Father: Frida Kahlo’s Intimate Relation to Epilepsy. Eur Neurol.
2021 May 19:1-5. doi: 10.1159/000516321. Epub ahead of print.
PMID: 34010835.
Online Full Text
Cascino GD, Tarquinio D, Wheless JW, Hogan RE, Sperling MR, Liow K, Desai J, Davis C, Rabinowicz AL, Carrazana E.
Lack of observed tolerance to diazepam nasal spray (Valtoco®) after long-term rescue therapy in patients with epilepsy: Interim results from a phase 3, open-label, repeat-dose safety study.
Epilepsy Behav. 2021 May 3;120:107983. doi: 10.1016/j.yebeh.2021.107983.
PubMed PMID: 33957437
Online Full Text PDF Link
Segal EB, Tarquinio D, Miller I, Wheless JW, Dlugos D, Biton V, Cascino GD, Desai J, Hogan RE, Liow K, Sperling MR, Vazquez B, Cook DF, Rabinowicz AL, Carrazana E.
Evaluation of diazepam nasal spray in patients with epilepsy concomitantly using maintenance benzodiazepines: An interim subgroup analysis from a phase 3, long-term, open-label safety study.
Epilepsia. 2021 May 4;. doi: 10.1111/epi.16901.
PubMed PMID: 33942315.
Open Access Online PDF
Nair DR, Laxer KD, Weber PB et al.
Nine-Year Prospective Efficacy And Safety Of Brain-Responsive Neurostimulation For Focal Epilepsy.
Neurology. 2020 Sep 1;95(9):e1244-e1256. doi: 10.1212/WNL.0000000000010154. Epub 2020 Jul 20.
PubMed PMID: 32690786; PubMed Central PMCID: PMC7538230.
Hauser SL, Bar-Or A, Cohen JA, Comi G, Correale J, Coyle PK, Cross AH, de Seze J, Leppert D, Montalban X, Selmaj K, Wiendl H, Kerloeguen C, Willi R, Li B, Kakarieka A, Tomic D, Goodyear A, Pingili R, Häring DA, Ramanathan K, Merschhemke M, Kappos L.
Ofatumumab versus Teriflunomide in Multiple Sclerosis.
N Engl J Med. 2020 Aug 6;383(6):546-557. doi: 10.1056/NEJMoa1917246.
PubMed PMID: 32757523.
Meador KJ, Pennell PB, May RC, Brown CA, Baker G, Bromley R, Loring DW, Cohen MJ.
Effects of periconceptional folate on cognition in children of women with epilepsy: NEAD study.
Neurology. 2020 Feb 18;94(7):e729-e740. doi: 10.1212/WNL.0000000000008757. Epub 2019 Dec 23.
PubMed PMID: 31871217; PubMed Central PMCID: PMC7176294.
Abstracts
Use of a Second Dose of Diazepam Nasal Spray Within 4 Hours and Effect on the Safety Profile in Patients with Seizure Clusters: Interim Results from a Phase 3, Open-Label, 12-Month Repeat Dose Safety Study.
Daniel Tarquinio, Eric B. Segal, Ian Miller, James W. Wheless, R. Edward Hogan, Victor Biton, Gregory D. Cascino, Michael R. Sperling, Kore Liow, Blanca Vazquez, Ricardo Ayala, Weldon Mauney, Jay Desai, Adrian L. Rabinowicz, Enrique Carrazana, for the DIAZ.001.05 Study Group.
Epilepsia Supplements December, 2020
Evaluation of Diazepam Nasal Spray in Patients with Epilepsy Concomitantly Using Maintenance Benzodiazepines: Interim Analysis from a Phase 3, Long-term, Open-label Safety Study.
Eric B. Segal, ; Daniel Tarquinio, Ian Miller, James W. Wheless, Dennis Dlugos, Ricardo Ayala,Victor Biton, Gregory D. Cascino, Jay Desai, R. Edward Hogan, Kore Liow, Weldon Mauney, Michael R. Sperling, Blanca Vazquez, David F. Cook, Adrian L. Rabinowicz, Enrique Carrazana for the DIAZ.001.05 Study Group.
Epilepsia Supplements December, 2020
Efficacy and Safety Of Adjunctive Padsevonil In Adults With Drug-Resistant Focal Seizures: A Double-Blind, Randomized, Placebo-Controlled Dose-Finding Trial.
Rademacher M, Toledo M, Van Paesschen W, Liow K, Esch M, Webster E, Wang N, Werhahn K, French J.
Epilepsia Supplements December, 2020
Vagal Nerve Stimulation (VNS) in genetic developmental epileptic encephalopathies (DEE): approach in highly specialized centers around the world.
Kwan P, Verner R, O’Brien T, El Tahry R, Keough K, Boggs J, Fahoum F, Greco T, Van Grunderbeek W, Sen A,Core-VNS Study Group.
Epilepsia Supplements December, 2020
CORE-VNS: A Prospective Outcomes Registry of Patients With Drug-resistant Epilepsy Treated With Vagus Nerve Stimulation Therapy.
Kwan P, Verner R, O’Brien T, El Tahry R, Keough K, Boggs J, Fahoum F, Greco T, Van Grunderbeek W, Sen A,Core-VNS Study Group. 2020.
Epilepsia Supplements December, 2020
Two-Part, Double-Blind, Placebo-Controlled, Inpatient, Dose-Ranging Efficacy Study of Staccato Alprazolam (STAP-001) in Patients with Epilepsy with a Predictable Seizure Pattern: Results from the Initial Open-Label Feasibility Part.
J French, K Liow, B Vazquez, P Klein, D Tarquinio, B Reich, R Small, J Isojarvi.
Neurology Supplements 2019
Wessels AM, Barbone JM, DiGregorio DT, Miller DS, Mullen JA, Sims JR. Lanabecestat: Rater performance and error characteristics of efficacy assessments in the DAYBREAK-ALZ study. CTAD Poster Abstract. J Prev Alzheimers Dis. 2018; 5(Supp 1):S188-S189.
Frank Nagy, Michael A. Rogawski, Hui Gong, Kore Liow, Sami Aboumater, Pavel Klein, Michael A. Gelfand, Cassie Jung, Stephen Wargacki, Rikin Mehta, Allen H. heller Pharmacokinetics of Diazepam Buccal Film in Adult Patients with Epilepsy: Comparison of Bioavailability with Periictal and Interictal Administration. Neurotherapeutics 2019.
Heller, T. Gong, K. Liow, S. Aboumatar, P. Klein, M. Gelfand, C. Jung, S. Wargacki, R. Mehta, M. Rogawski Pharmacokinetics of Diazepam Buccal Soluble Film in Adult Patients with Epilepsy. Epilepsia 2018.
C. Jung, J. Dubow, T. Gong, K. Liow, S. Aboumatar, P. Klein, M. Gelfand, S. Wargacki, R. Mehta, M. Rogawski, A. Heller. The Usability of Diazepam Buccal Soluble Film (DBSF) An Oral Treatment For The Management of Acute Bouts of Cluster Seizures In Adult Patients With Epilepsy. Epilepsia 2018.
Faculty National and International Presentations
2021 Alzheimer’s Association International Conference, Denver, CO, Wednesday July 26th
Safety Profile of Valtoco® (diazepam nasal spray) in Patients with Epilepsy: Final Results From a Phase 3, Open-Label, 12-Month Repeat Dose Safety Study. Wheless JW, Sperling MR, Liow K, Vazquez B, Segal EB, Miller I, Hogan RE, Tarquinio D, Mauney W, DeSai J, Dlugos D, Biton V, Cascino G, Carrazana E; Rabinowicz AL, for the DIAZ.001.05 Study Group. American Managed Care Pharmacist (AMCP) Annual Meeting, Virtual. April 2021
Time to Second Doses in Emergency Seizure Patients Treated with Valtoco® (diazepam nasal spray) Across 24 Hours: Subgroup Results From a Completed Phase 3, Open-label, Repeat Dose Safety Study. Wheless JW, Sperling MR, Liow K, Vazquez B, Segal EB, Miller I, Hogan RE, Tarquinio D, Mauney W, DeSai J, Dlugos D, Biton V, Cascino G, Carrazana E; Rabinowicz AL, for the DIAZ.001.05 Study Group. American Managed Care Pharmacist (AMCP) Annual Meeting, Virtual. April 2021
Evaluation of Diazepam Nasal Spray in Patients with Epilepsy Concomitantly Using Maintenance Benzodiazepines: Interim Analysis from a Phase 3, Long-term, Open-label Safety Study. Segal E, Tarquinio D, Miller I, Wheless J, Dlugos D, Biton V, Cascino G, Desai J, Hogan E, Liow K, Mauney W, Sperling M, Cook D, Rabinowicz A, Carrazana E, for the DIAZ.001.05 Study Group. American Academy of Neurology (AAN), Annual Meeting, Virtual. April 2021
Safety Profile of Valtoco® (diazepam nasal spray) in Patients With Epilepsy: Final Results From a Phase 3, Open-Label, 12-Month Repeat Dose Safety Study. Wheless JW, Sperling MR, Liow K, Vazquez B, Segal EB, Miller I, Hogan RE, Tarquinio D, Mauney W, DeSai J, Dlugos D, Biton V, Cascino G, Carrazana E; Rabinowicz AL, for the DIAZ.001.05 Study Group. American Academy of Neurology (AAN), Annual Meeting, Virtual. April 2021
Time to Second Doses in Emergency Seizure Patients Treated with Valtoco® (diazepam nasal spray) Across 24 Hours: Subgroup Results From a Completed Phase 3, Open-label, Repeat Dose Safety Study. Wheless JW, Sperling MR, Liow K, Vazquez B, Segal EB, Miller I, Hogan RE, Tarquinio D, Mauney W, DeSai J, Dlugos D, Biton V, Cascino G, Carrazana E; Rabinowicz AL, for the DIAZ.001.05 Study Group. American Academy of Neurology (AAN), Annual Meeting, Virtual. April 2021
Use of a Second Dose of Diazepam Nasal Spray Within 4 Hours and Effect on the Safety Profile in Patients with Seizure Clusters: Interim Results from a Phase 3, Open-Label, 12-Month Repeat Dose Safety Study. Daniel Tarquinio, Eric B. Segal, Ian Miller, James W. Wheless, R. Edward Hogan, Victor Biton, Gregory D. Cascino, Michael R. Sperling, Kore Liow, Blanca Vazquez, Ricardo Ayala, Weldon Mauney, Jay Desai, Adrian L. Rabinowicz, Enrique Carrazana, for the DIAZ.001.05 Study Group. 74th Annual Meeting of the American Epilepsy Society Meeting, Seattle, WA, Dec 2020.
Evaluation of Diazepam Nasal Spray in Patients with Epilepsy Concomitantly Using Maintenance Benzodiazepines: Interim Analysis from a Phase 3, Long-term, Open-label Safety Study. Eric B. Segal, ; Daniel Tarquinio, Ian Miller, James W. Wheless, Dennis Dlugos, Ricardo Ayala,Victor Biton, Gregory D. Cascino, Jay Desai, R. Edward Hogan, Kore Liow, Weldon Mauney, Michael R. Sperling, Blanca Vazquez, David F. Cook, Adrian L. Rabinowicz, Enrique Carrazana for the DIAZ.001.05 Study Group. 74th Annual Meeting of the American Epilepsy Society Meeting, Seattle, WA, Dec 2020.
Efficacy and Safety Of Adjunctive Padsevonil In Adults With Drug-Resistant Focal Seizures: A Double-Blind, Randomized, Placebo-Controlled Dose-Finding Trial. Rademacher M, Toledo M, Van Paesschen W, Liow K, Esch M, Webster E, Wang N, Werhahn K, French J. 74th Annual Meeting of the American Epilepsy Society Meeting, Seattle, WA, Dec 2020.
Vagal Nerve Stimulation (VNS) in genetic developmental epileptic encephalopathies (DEE):
approach in highly specialized centers around the world. Kwan P, Verner R, O’Brien T, El Tahry R, Keough K, Boggs J, Fahoum F, Greco T, Van Grunderbeek W, Sen A,Core-VNS Study Group. 2020 74th Annual Meeting of the American Epilepsy Society Meeting, Seattle, WA, Dec 2020.
CORE-VNS: A Prospective Outcomes Registry of Patients With Drug-resistant Epilepsy Treated With Vagus Nerve Stimulation Therapy. Kwan P, Verner R, O’Brien T, El Tahry R, Keough K, Boggs J, Fahoum F, Greco T, Van Grunderbeek W, Sen A,Core-VNS Study Group. 2020 74th Annual Meeting of the American Epilepsy Society Meeting, Seattle, WA, Dec 2020.
A Randomized Phase 3 Study in Mild Alzheimer’s Disease (DAYBREAK-ALZ). Sims JR, Zimmer J, Wessels A, Selzler K, Andersen SW, Landry J, Mullen J, Barker P, Stern R, Vellas B, Boada M, Cohen S, MacSweeny E, Tariot P. Lanabecestat. 14th International Conference on Alzheimer’s and Parkinson’s Disease (ADPD) 2019.
Willis B, James D, Scott S, Bragg S, Mullen J, Downing A, Selzler K, Wessels A, Zimmer J, Sims J. Lanabecestat: Biomarker results from two Phase 3 studies in Alzheimer’s disease. 14th International Conference on Alzheimer’s and Parkinson’s Disease (ADPD) 2019.
Mintun M, Shcherbinin S, Charil A, Zimmer J, Andersen S, Landry J, Mullen J, Wessels A, Bragg S, Selzler K, Fleisher A, Sims J. Lanabecestat: Neuroimaging results from two Phase 3 studies in Alzheimer’s disease. 14th International Conference on Alzheimer’s and Parkinson’s Disease (ADPD) 2019.
Two-Part, Double-Blind, Placebo-Controlled, Inpatient, Dose-Ranging Efficacy Study of Staccato Alprazolam (STAP-001) in Patients with Epilepsy with a Predictable Seizure Pattern: Results from the Initial Open-Label Feasibility Part. J French, K Liow, B Vazquez, P Klein, D Tarquinio, B Reich, R Small, J Isojarvi. American Academy of Neurology Annual Meeting, Philadelphia, PA April, 2019
Pharmacokinetics of Diazepam Buccal Film in Adult Patients with Epilepsy: Comparison of Bioavailability with Periictal and Interictal Administration. American Society of Experimental Therapeutics, Bethesda, MD, March 2019.