Publications

Publications

PubMed Peer Reviewed Publications and National
and International Presentations (Recent 2019-2021)

Student or Resident Led Projects
PubMed Peer Reviewed Publications

Early impact of the COVID-19 pandemic on outpatient Migraine care in Hawaii: Results of a quality improvement survey.
Smith M, Nakamoto M, Crocker J, Tiffany Morden F, Liu K, Ma E, Chong A, Van N, Vajjala V, Carrazana E, Viereck J, Liow K.
Headache. 2020 Dec 14;. doi: 10.1111/head.14030. PubMed PMID: 33316097

Epilepsy in the time of COVID-19.
Nakamoto M, Carrazana E, Viereck J, Liow K.
Acta Neurol Scand. 2020 Oct 11;. doi: 10.1111/ane.13360. PubMed PMID: 33043445; PubMed Central PMCID: PMC7675556

Role Of Psychiatric, Cardiovascular, Socioeconomic, And Demographic Risk Factors On Idiopathic Normal Pressure Hydrocephalus: A Retrospective Case-Control Study.
Ghaffari-Rafi A, Gorenflo R, Hu H, Viereck J, Liow K.
Clin Neurol Neurosurg. 2020 Jun;193:105836. doi: 10.1016/j.clineuro.2020.105836. Epub 2020 Apr 28. PubMed PMID: 32371292.

Medical School Hotline: Hawai’i Pacific Neuroscience Summer Internship Program.
Smith M, Wicknick A, Liow KK.
Hawaii J Health Soc Welf. 2020 Mar 1;79(3):82-85. PubMed PMID: 32190840; PubMed Central PMCID: PMC7061031

Presentation of psychogenic nonepileptic seizures in Hawaii’s ethnoracially diverse.

Ho R, Ocol J, Lu C, Dolim S, Yang M, Carrazana E, Liow KK. 
Epilepsy Behav. 2019 Jul;96:150-154. doi: 10.1016/j.yebeh.2019.04.024. Epub 2019 May 28. PubMed PMID: 31146179.

Zika Virus: Relevance to the State of Hawai’i.
Lew WJ, Tsai WY, Balaraman V, Liow KK, Tyson J, Wang WK.
Hawaii J Med Public Health. 2019 Apr;78(4):123-127. PubMed PMID: 30972234; PubMed Central PMCID: PMC6452016.

Inappropriate Laughter and Behaviours: How, What, and Why? Case of an Adult with Undiagnosed Gelastic Seizure with Hypothalamic Hamartoma.
Beckwith NL, Khil JC, Teng J, Liow KK, Smith A, Luna J.
Hawaii J Med Public Health. 2018 Dec;77(12):319-324. PubMed PMID: 30533284; PubMed Central PMCID: PMC6277842.

 

Abstract

Sociodemographic Disparities and Risk Factors in Diagnosing Idiopathic Intracranial Hypertension: A Retrospective Case-Control Study.
Frances Morden Charissa Tan, Enrique Carrazana, Jason Viereck, Kore Kai Liow, Arash Ghaffari-Rafi.
J of Neurosurgery Supplements 2021 

 

Assessing U.S. Demographic Recruitment Bias in 21st Century Neurosurgery Clinical Trials.
Taylor E, Buffenstein I, Kāneakua B, Ghaffari-Rafi A, Viereck J, Carrazana E, Liow K.
J of Neurosurgery Supplements 2021 

Effectiveness of Dual Migraine therapy with CGRP Antagonists and OnabotulinumtoxinA Injections: Experience from a Single Migraine Center in Hawaii.  
Lee J, Liang Y, Newman B, Tamanaha R, Toni T, Carrazana E, Vajjala V, Viereck J, Liow K.
Cephalgia 40 (IS), 2020 Pg. 104

COVID-19 Pandemic Effect on Epilepsy Outpatient Care at a Regional Referral Center in Hawaii.
Nakamoto M, Smith M, Crocker J, Morden F, Liu K, Ma E, Chong A, Van N, Mitchell C, Zhu E, Dang N, Carrazana E, Viereck J, Liow K.
Epilepsia Supplements December, 2020

 

Biopsychological predictors in patients with psychogenic non-epileptic seizures from a comprehensive epilepsy center in Hawai’i
C Lu, R Ho, J Ocol, M Yang, E Carrazana, K Liow,  
Epilepsia Supplements December, 2019

 

Use of Cannabinoids in Patients with Epilepsy from a Comprehensive Epilepsy Center in Hawaii. R
Ho, J Zhang, C Lu, B Fong, K Oura, A Shipman, H Hu, A Appana, G Slattery, E Carrazana , K Liow, 
Epilepsia Supplements December, 2019

 

Presentation of PNES in Hawaii’s Ethnoculturally Diverse Patients
Ocol J, Ho R, Lu C, Dolim S, Yang M, Kaplan A, Wilson C, Lee E, Carrazana E. Liow K. 2018
American Epilepsy Society Meeting, Epilepsia 2018. 

Recent Student led National Publications

Early impact of the COVID-19 pandemic on outpatient Migraine care in Hawaii: Results of a quality improvement survey.
Smith M, Nakamoto M, Crocker J, Tiffany Morden F, Liu K, Ma E, Chong A, Van N, Vajjala V, Carrazana E, Viereck J, Liow K. 
Headache. 2020 Dec 14;. doi: 10.1111/head.14030. PubMed PMID: 33316097

Epilepsy in the time of COVID-19.
Nakamoto M, Carrazana E, Viereck J, Liow K.
Acta Neurol Scand. 2020 Oct 11;. doi: 10.1111/ane.13360. PubMed PMID: 33043445; PubMed Central PMCID: PMC7675556

Role Of Psychiatric, Cardiovascular, Socioeconomic, And Demographic Risk Factors On Idiopathic Normal Pressure Hydrocephalus: A Retrospective Case-Control Study.
Ghaffari-Rafi A, Gorenflo R, Hu H, Viereck J, Liow K.
Clin Neurol Neurosurg. 2020 Jun;193:105836. doi: 10.1016/j.clineuro.2020.105836. Epub 2020 Apr 28. PubMed PMID: 32371292.

Medical School Hotline: Hawai’i Pacific Neuroscience Summer Internship Program.
Smith M, Wicknick A, Liow KK.
Hawaii J Health Soc Welf. 2020 Mar 1;79(3):82-85. PubMed PMID: 32190840; PubMed Central PMCID: PMC7061031

Effectiveness of Dual Migraine therapy with CGRP Antagonists and OnabotulinumtoxinA Injections: Experience from a Single Migraine Center in Hawaii. 
Lee J, Liang Y, Newman B, Tamanaha R, Toni T, Carrazana E, Vajjala V, Viereck J, Liow K. 
Cephalgia 40 (IS), 2020 Pg. 104

COVID-19 Pandemic Effect on Epilepsy Outpatient Care at a Regional Referral Center in Hawaii. 
Nakamoto M, Smith M, Crocker J, Morden F, Liu K, Ma E, Chong A, Van N, Mitchell C, Zhu E, Dang N, Carrazana E, Viereck J, Liow K.
Epilepsia Supplements December, 2020

National or International Presentations

Sociodemographic Disparities and Risk Factors in Diagnosing Idiopathic Intracranial Hypertension: A Retrospective Case-Control Study.
Frances Morden, Charissa Tan, Enrique Carrazana, Jason Viereck, Kore Kai Liow, Arash Ghaffari-Rafi.
American Association of Neurological Surgeons, Annual Scietific Meeting, Orlando, FL, August 2021

Assessing U.S. Demographic Recruitment Bias in 21st Century Neurosurgery Clinical Trials. Taylor E, Buffenstein I, Kāneakua B, Ghaffari-Rafi A, Viereck J, Carrazana E, Liow K. American Association of Neurological Surgeons, Annual Scientific Meeting, Orlando, FL, August 2021 

Factors that Affect the Employability of Patients with Epilepsy in Hawaii: A Look at Race, Comorbidities, and Marital Status.
Gorenflo R, Kimball L, Taeza B, Gan A, Viereck J, Carrazana E, Liow K.
American Academy of Neurology Annual Meeting, April 2021

Effectiveness of Dual Migraine therapy with CGRP Antagonists and OnabotulinumtoxinA Injections: Experience from a Single Migraine Center in Hawaii.
Lee J, Liang Y, Newman B, Tamanaha R, Toni T, Carrazana E, Vajjala V, Viereck J, Liow K. 2020 International Headache Society Annual Meeting

COVID-19 Pandemic Effect on Epilepsy Outpatient Care at a Regional Referral Center in Hawaii.
Nakamoto M, Smith M, Crocker J, Morden F, Liu K, Ma E, Chong A, Van N, Mitchell C, Zhu E, Dang N, Carrazana E, Viereck J, Liow K.
74th Annual Meeting of the American Epilepsy Society Meeting, Seattle, WA, Dec 2020.

Use of Cannabinoids in Patients with Epilepsy from a Comprehensive Epilepsy Center in Hawaii. 
R Ho, J Zhang, C Lu, B Fong, K Oura, A Shipman, H Hu, A Appana, G Slattery, E Carrazana, K Liow, 
American Epilepsy Society Annual Meeting, Baltimore, MD, Dec, 2019

Biopsychological predictors in patients with psychogenic non-epileptic seizures from a comprehensive epilepsy center in Hawai’i,
C Lu, R Ho, J Ocol, M Yang, E Carrazana, K Liow
American Epilepsy Society Annual Meeting, Baltimore, MD, Dec, 2019 

Recent Student Led Research Presented at National Meetings

Factors that Affect the Employability of Patients with Epilepsy in Hawaii: A Look at Race, Comorbidities, and Marital Status.
Gorenflo R, Kimball L, Taeza B, Gan A, Carrazana E, Liow K. 
American Academy of Neurology Annual Meeting, April 2021

Effectiveness of Dual Migraine therapy with CGRP Antagonists and OnabotulinumtoxinA Injections: Experience from a Single Migraine Center in Hawaii.  
Lee J, Liang Y, Newman B, Tamanaha R, Toni T, Carrazana E, Vajjala V, Viereck J, Liow K. 
2020 International Headache Society Annual Meeting

COVID-19 Pandemic Effect on Epilepsy Outpatient Care at a Regional Referral Center in Hawaii.
Nakamoto M, Smith M, Crocker J, Morden F, Liu K, Ma E, Chong A, Van N, Mitchell C, Zhu E, Dang N, Carrazana E, Viereck J, Liow K. 
74th Annual Meeting of the American Epilepsy Society Meeting, Seattle, WA, Dec 2020

Use of Cannabinoids in Patients with Epilepsy from a Comprehensive Epilepsy Center in Hawaii. 
American Epilepsy Society Annual Meeting, Baltimore, MD, Dec, 2019

Biopsychological predictors in patients with psychogenic non-epileptic seizures from a comprehensive epilepsy center in Hawai’i, 
American Epilepsy Society Annual Meeting, Baltimore, MD, Dec, 2019

Neuroscience Faculty Recent Research Work

PubMed Peer Reviewed Publications

Carrazana EJ.
Portrait of My Father: Frida Kahlo’s Intimate Relation to Epilepsy. Eur Neurol.
2021 May 19:1-5. doi: 10.1159/000516321. Epub ahead of print. 
PMID: 34010835.
Online Full Text

 

Cascino GD, Tarquinio D, Wheless JW, Hogan RE, Sperling MR, Liow K, Desai J, Davis C, Rabinowicz AL, Carrazana E. 
Lack of observed tolerance to diazepam nasal spray (Valtoco®) after long-term rescue therapy in patients with epilepsy: Interim results from a phase 3, open-label, repeat-dose safety study. 
Epilepsy Behav. 2021 May 3;120:107983. doi: 10.1016/j.yebeh.2021.107983.
PubMed PMID: 33957437 
Online Full Text PDF Link

 

Segal EB, Tarquinio D, Miller I, Wheless JW, Dlugos D, Biton V, Cascino GD, Desai J, Hogan RE, Liow K, Sperling MR, Vazquez B, Cook DF, Rabinowicz AL, Carrazana E. 
Evaluation of diazepam nasal spray in patients with epilepsy concomitantly using maintenance benzodiazepines: An interim subgroup analysis from a phase 3, long-term, open-label safety study. 
Epilepsia. 2021 May 4;. doi: 10.1111/epi.16901.  
PubMed PMID: 33942315.
Open Access Online PDF 

 

Nair DR, Laxer KD, Weber PB et al. 
Nine-Year Prospective Efficacy And Safety Of Brain-Responsive Neurostimulation For Focal Epilepsy. 
Neurology. 2020 Sep 1;95(9):e1244-e1256. doi: 10.1212/WNL.0000000000010154. Epub 2020 Jul 20. 
PubMed PMID: 32690786; PubMed Central PMCID: PMC7538230.

 

Hauser SL, Bar-Or A, Cohen JA, Comi G, Correale J, Coyle PK, Cross AH, de Seze J, Leppert D, Montalban X, Selmaj K, Wiendl H, Kerloeguen C, Willi R, Li B, Kakarieka A, Tomic D, Goodyear A, Pingili R, Häring DA, Ramanathan K, Merschhemke M, Kappos L. 
Ofatumumab versus Teriflunomide in Multiple Sclerosis. 
N Engl J Med. 2020 Aug 6;383(6):546-557. doi: 10.1056/NEJMoa1917246. 
PubMed PMID: 32757523.

 

Meador KJ, Pennell PB, May RC, Brown CA, Baker G, Bromley R, Loring DW, Cohen MJ. 
Effects of periconceptional folate on cognition in children of women with epilepsy: NEAD study. 
Neurology. 2020 Feb 18;94(7):e729-e740. doi: 10.1212/WNL.0000000000008757. Epub 2019 Dec 23. 
PubMed PMID: 31871217; PubMed Central PMCID: PMC7176294.

Abstracts

Use of a Second Dose of Diazepam Nasal Spray Within 4 Hours and Effect on the Safety Profile in Patients with Seizure Clusters: Interim Results from a Phase 3, Open-Label, 12-Month Repeat Dose Safety Study. 
Daniel Tarquinio, Eric B. Segal, Ian Miller, James W. Wheless, R. Edward Hogan, Victor Biton, Gregory D. Cascino, Michael R. Sperling, Kore Liow, Blanca Vazquez, Ricardo Ayala, Weldon Mauney, Jay Desai, Adrian L. Rabinowicz, Enrique Carrazana, for the DIAZ.001.05 Study Group.
Epilepsia Supplements December, 2020

 

Evaluation of Diazepam Nasal Spray in Patients with Epilepsy Concomitantly Using Maintenance Benzodiazepines: Interim Analysis from a Phase 3, Long-term, Open-label Safety Study.  
Eric B. Segal, ; Daniel Tarquinio, Ian Miller, James W. Wheless, Dennis Dlugos, Ricardo Ayala,Victor Biton, Gregory D. Cascino, Jay Desai, R. Edward Hogan, Kore Liow, Weldon Mauney, Michael R. Sperling, Blanca Vazquez, David F. Cook, Adrian L. Rabinowicz, Enrique Carrazana for the DIAZ.001.05 Study Group.
Epilepsia Supplements December, 2020

 

Efficacy and Safety Of Adjunctive Padsevonil In Adults With Drug-Resistant Focal Seizures: A Double-Blind, Randomized, Placebo-Controlled Dose-Finding Trial.
Rademacher M, Toledo M, Van Paesschen W, Liow K, Esch M, Webster E, Wang N, Werhahn K, French J.
Epilepsia Supplements December, 2020

 

Vagal Nerve Stimulation (VNS) in genetic developmental epileptic encephalopathies (DEE): approach in highly specialized centers around the world.
Kwan P, Verner R, O’Brien T, El Tahry R, Keough K, Boggs J, Fahoum F, Greco T, Van Grunderbeek W, Sen A,Core-VNS Study Group. 

Epilepsia Supplements December, 2020

 

CORE-VNS: A Prospective Outcomes Registry of Patients With Drug-resistant Epilepsy Treated With Vagus Nerve Stimulation Therapy.   
Kwan P, Verner R, O’Brien T, El Tahry R, Keough K, Boggs J, Fahoum F, Greco T, Van Grunderbeek W, Sen A,Core-VNS Study Group. 2020.
Epilepsia Supplements December, 2020 

 

Two-Part, Double-Blind, Placebo-Controlled, Inpatient, Dose-Ranging Efficacy Study of Staccato Alprazolam (STAP-001) in Patients with Epilepsy with a Predictable Seizure Pattern: Results from the Initial Open-Label Feasibility Part.  
J French, K Liow, B Vazquez, P Klein, D Tarquinio, B Reich, R Small, J Isojarvi.
Neurology Supplements 2019

 

Wessels AM, Barbone JM, DiGregorio DT, Miller DS, Mullen JA, Sims JR. Lanabecestat: Rater performance and error characteristics of efficacy assessments in the DAYBREAK-ALZ study. CTAD Poster Abstract. J Prev Alzheimers Dis. 2018; 5(Supp 1):S188-S189.

 

Frank Nagy, Michael A. Rogawski, Hui Gong, Kore Liow, Sami Aboumater, Pavel Klein, Michael A. Gelfand, Cassie Jung, Stephen Wargacki, Rikin Mehta, Allen H. heller Pharmacokinetics of Diazepam Buccal Film in Adult Patients with Epilepsy: Comparison of Bioavailability with Periictal and Interictal Administration.  Neurotherapeutics 2019.

Heller, T. Gong, K. Liow, S. Aboumatar, P. Klein, M. Gelfand, C. Jung, S. Wargacki, R. Mehta, M. Rogawski Pharmacokinetics of Diazepam Buccal Soluble Film in Adult Patients with Epilepsy.
Epilepsia 2018.

C. Jung, J. Dubow, T. Gong, K. Liow, S. Aboumatar, P. Klein, M. Gelfand, S. Wargacki, R. Mehta, M. Rogawski, A. Heller. The Usability of Diazepam Buccal Soluble Film (DBSF) An Oral Treatment For The Management of Acute Bouts of Cluster Seizures In Adult Patients With Epilepsy. Epilepsia 2018.

Recent Neuroscience Faculty Research work at Clinical Research Center
Published or Presented Nationally

Nair DR, Laxer KD, Weber PB et al. Nine-Year Prospective Efficacy And Safety Of Brain-Responsive Neurostimulation For Focal Epilepsy. Neurology. 2020 Sep 1;95(9):e1244-e1256. doi: 10.1212/WNL.0000000000010154. Epub 2020 Jul 20. PubMed PMID: 32690786; PubMed Central PMCID: PMC7538230.

Hauser SL, Bar-Or A, Cohen JA, Comi G, Correale J, Coyle PK, Cross AH, de Seze J, Leppert D, Montalban X, Selmaj K, Wiendl H, Kerloeguen C, Willi R, Li B, Kakarieka A, Tomic D, Goodyear A, Pingili R, Häring DA, Ramanathan K, Merschhemke M, Kappos L. Ofatumumab versus Teriflunomide in Multiple Sclerosis. N Engl J Med. 2020 Aug 6;383(6):546-557. doi: 10.1056/NEJMoa1917246. PubMed PMID: 32757523

Vagal Nerve Stimulation (VNS) in genetic developmental epileptic encephalopathies (DEE): approach in highly specialized centers around the world. Kwan P, Verner R, O’Brien T, El Tahry R, Keough K, Boggs J, Fahoum F, Greco T, Van Grunderbeek W, Sen A,Core-VNS Study Group. Epilepsia Supplements December, 2020

Use of a Second Dose of Diazepam Nasal Spray Within 4 Hours and Effect on the Safety Profile in Patients with Seizure Clusters: Interim Results from a Phase 3, Open-Label, 12-Month Repeat Dose Safety Study.  Daniel Tarquinio, Eric B. Segal, Ian Miller, James W. Wheless, R. Edward Hogan, Victor Biton, Gregory D. Cascino, Michael R. Sperling, Kore Liow, Blanca Vazquez, Ricardo Ayala, Weldon Mauney, Jay Desai, Adrian L. Rabinowicz, Enrique Carrazana, for the DIAZ.001.05 Study Group. Epilepsia Supplements December, 2020

Efficacy and Safety Of Adjunctive Padsevonil In Adults With Drug-Resistant Focal Seizures: A Double-Blind, Randomized, Placebo-Controlled Dose-Finding Trial.  Rademacher M, Toledo M, Van Paesschen W, Liow K, Esch M, Webster E, Wang N, Werhahn K, French J. Epilepsia Supplements December, 2020

Evaluation of Diazepam Nasal Spray in Patients with Epilepsy Concomitantly Using Maintenance Benzodiazepines: Interim Analysis from a Phase 3, Long-term, Open-label Safety Study.   Eric B. Segal, ; Daniel Tarquinio, Ian Miller, James W. Wheless, Dennis Dlugos, Ricardo Ayala,Victor Biton, Gregory D. Cascino, Jay Desai, R. Edward Hogan, Kore Liow, Weldon Mauney, Michael R. Sperling, Blanca Vazquez, David F. Cook, Adrian L. Rabinowicz, Enrique Carrazana for the DIAZ.001.05 Study Group. Epilepsia Supplements December, 2020

CORE-VNS: A Prospective Outcomes Registry of Patients With Drug-resistant Epilepsy Treated With Vagus Nerve Stimulation Therapy.   Kwan P, Verner R, O’Brien T, El Tahry R, Keough K, Boggs J, Fahoum F, Greco T, Van Grunderbeek W, Sen A,Core-VNS Study Group. 2020. Epilepsia Supplements December, 2020

Wessels AM, Barbone JM, DiGregorio DT, Miller DS, Mullen JA, Sims JR. Lanabecestat: Rater performance and error characteristics of efficacy assessments in the DAYBREAK-ALZ study. CTAD Poster Abstract. J Prev Alzheimers Dis. 2018; 5(Supp 1):S188-S189

Two-Part, Double-Blind, Placebo-Controlled, Inpatient, Dose-Ranging Efficacy Study of Staccato Alprazolam (STAP-001) in Patients with Epilepsy with a Predictable Seizure Pattern: Results from the Initial Open-Label Feasibility Part J French, K Liow, B Vazquez, P Klein, D Tarquinio, B Reich, R Small, J Isojarvi. Neurology Supplements 2019

Frank Nagy, Michael A. Rogawski, Hui Gong, Kore Liow, Sami Aboumater, Pavel Klein, Michael A. Gelfand, Cassie Jung, Stephen Wargacki, Rikin Mehta, Allen H. heller Pharmacokinetics of Diazepam Buccal Film in Adult Patients with Epilepsy: Comparison of Bioavailability with Periictal and Interictal Administration.  Neurotherapeutics 2019.

Safety Profile of Valtoco® (diazepam nasal spray) in Patients with Epilepsy: Final Results From a Phase 3, Open-Label, 12-Month Repeat Dose Safety Study. Wheless JW, Sperling MR, Liow K, Vazquez B, Segal EB, Miller I, Hogan RE, Tarquinio D, Mauney W, DeSai J, Dlugos D, Biton V, Cascino G, Carrazana E; Rabinowicz AL, for the DIAZ.001.05 Study Group. American Managed Care Pharmacist (AMCP) Annual Meeting, Virtual. April 2021

Time to Second Doses in Emergency Seizure Patients Treated with Valtoco® (diazepam nasal spray) Across 24 Hours: Subgroup Results From a Completed Phase 3, Open-label, Repeat Dose Safety Study. Wheless JW, Sperling MR, Liow K, Vazquez B, Segal EB, Miller I, Hogan RE, Tarquinio D, Mauney W, DeSai J, Dlugos D, Biton V, Cascino G, Carrazana E; Rabinowicz AL, for the DIAZ.001.05 Study Group. American Managed Care Pharmacist (AMCP) Annual Meeting, Virtual. April 2021

Evaluation of Diazepam Nasal Spray in Patients with Epilepsy Concomitantly Using Maintenance Benzodiazepines: Interim Analysis from a Phase 3, Long-term, Open-label Safety Study. Segal E, Tarquinio D, Miller I, Wheless J, Dlugos D, Biton V, Cascino G, Desai J, Hogan E, Liow K, Mauney W, Sperling M, Cook D, Rabinowicz A, Carrazana E, for the DIAZ.001.05 Study Group. American Academy of Neurology (AAN), Annual Meeting, Virtual. April 2021

Safety Profile of Valtoco® (diazepam nasal spray) in Patients With Epilepsy: Final Results From a Phase 3, Open-Label, 12-Month Repeat Dose Safety Study. Wheless JW, Sperling MR, Liow K, Vazquez B, Segal EB, Miller I, Hogan RE, Tarquinio D, Mauney W, DeSai J, Dlugos D, Biton V, Cascino G, Carrazana E; Rabinowicz AL, for the DIAZ.001.05 Study Group. American Academy of Neurology (AAN), Annual Meeting, Virtual. April 2021

Time to Second Doses in Emergency Seizure Patients Treated with Valtoco® (diazepam nasal spray) Across 24 Hours: Subgroup Results From a Completed Phase 3, Open-label, Repeat Dose Safety Study. Wheless JW, Sperling MR, Liow K, Vazquez B, Segal EB, Miller I, Hogan RE, Tarquinio D, Mauney W, DeSai J, Dlugos D, Biton V, Cascino G, Carrazana E; Rabinowicz AL, for the DIAZ.001.05 Study Group. American Academy of Neurology (AAN), Annual Meeting, Virtual. April 2021

Use of a Second Dose of Diazepam Nasal Spray Within 4 Hours and Effect on the Safety Profile in Patients with Seizure Clusters: Interim Results from a Phase 3, Open-Label, 12-Month Repeat Dose Safety Study.  Daniel Tarquinio, Eric B. Segal, Ian Miller, James W. Wheless, R. Edward Hogan, Victor Biton, Gregory D. Cascino, Michael R. Sperling, Kore Liow, Blanca Vazquez, Ricardo Ayala, Weldon Mauney, Jay Desai, Adrian L. Rabinowicz, Enrique Carrazana, for the DIAZ.001.05 Study Group. 74th Annual Meeting of the American Epilepsy Society Meeting, Seattle, WA, Dec 2020.

Evaluation of Diazepam Nasal Spray in Patients with Epilepsy Concomitantly Using Maintenance Benzodiazepines: Interim Analysis from a Phase 3, Long-term, Open-label Safety Study.   Eric B. Segal, ; Daniel Tarquinio, Ian Miller, James W. Wheless, Dennis Dlugos, Ricardo Ayala,Victor Biton, Gregory D. Cascino, Jay Desai, R. Edward Hogan, Kore Liow, Weldon Mauney, Michael R. Sperling, Blanca Vazquez, David F. Cook, Adrian L. Rabinowicz, Enrique Carrazana for the DIAZ.001.05 Study Group. 74th Annual Meeting of the American Epilepsy Society Meeting, Seattle, WA, Dec 2020.

Efficacy and Safety Of Adjunctive Padsevonil In Adults With Drug-Resistant Focal Seizures: A Double-Blind, Randomized, Placebo-Controlled Dose-Finding Trial.  Rademacher M, Toledo M, Van Paesschen W, Liow K, Esch M, Webster E, Wang N, Werhahn K, French J. 74th Annual Meeting of the American Epilepsy Society Meeting, Seattle, WA, Dec 2020.

Vagal Nerve Stimulation (VNS) in genetic developmental epileptic encephalopathies (DEE):approach in highly specialized centers around the world. Kwan P, Verner R, O’Brien T, El Tahry R, Keough K, Boggs J, Fahoum F, Greco T, Van Grunderbeek W, Sen A,Core-VNS Study Group. 2020 74th Annual Meeting of the American Epilepsy Society Meeting, Seattle, WA, Dec 2020.

CORE-VNS: A Prospective Outcomes Registry of Patients With Drug-resistant Epilepsy Treated With Vagus Nerve Stimulation Therapy.   Kwan P, Verner R, O’Brien T, El Tahry R, Keough K, Boggs J, Fahoum F, Greco T, Van Grunderbeek W, Sen A,Core-VNS Study Group. 2020 74th Annual Meeting of the American Epilepsy Society Meeting, Seattle, WA, Dec 2020.

A Randomized Phase 3 Study in Mild Alzheimer’s Disease (DAYBREAK-ALZ). Sims JR, Zimmer J, Wessels A, Selzler K, Andersen SW, Landry J, Mullen J, Barker P, Stern R, Vellas B, Boada M, Cohen S, MacSweeny E, Tariot P. Lanabecestat.  14th International Conference on Alzheimer’s and Parkinson’s Disease (ADPD) 2019.

Use of Cannabinoids in Patients with Epilepsy from a Comprehensive Epilepsy Center in Hawaii. R Ho, J Zhang, C Lu, B Fong, K Oura, A Shipman, H Hu, A Appana, G Slattery, E Carrazana , K Liow,  American Epilepsy Society Annual Meeting, Baltimore, MD, Dec, 2019

Biopsychological predictors in patients with psychogenic non-epileptic seizures from a comprehensive epilepsy center in Hawai’i, ,C Lu, R Ho, J Ocol, M Yang, E Carrazana, K Liow American Epilepsy Society Annual Meeting, Baltimore, MD, Dec, 2019 

Willis B, James D, Scott S, Bragg S, Mullen J, Downing A, Selzler K, Wessels A, Zimmer J, Sims J. Lanabecestat: Biomarker results from two Phase 3 studies in Alzheimer’s disease. 14th International Conference on Alzheimer’s and Parkinson’s Disease (ADPD) 2019.

 Mintun M, Shcherbinin S, Charil A, Zimmer J, Andersen S, Landry J, Mullen J, Wessels A, Bragg S, Selzler K, Fleisher A, Sims J. Lanabecestat:  Neuroimaging results from two Phase 3 studies in Alzheimer’s disease. 14th International Conference on Alzheimer’s and Parkinson’s Disease (ADPD) 2019

Epilepsy in the time of COVID-19

Nakamoto M, Carranza E, Viereck J, Liow K. Epilepsy in the time of COVID-19.

Acta Neurol Scand. 2020;00:1-3

Read Online

Ofatumumab versus Teriflunomide in Multiple Sclerosis

Hauser SL, Bar-Or A, Cohen JA, Comi G, Correale J, Coyle PK, Cross AH, de Seze J, Leppert D, Montalban X, Selmaj K, Wiendl H, Kerloeguen C, Willi R, Li B, Kakarieka A, Tomic D, Goodyear A, Pingili R, Häring DA, Ramanathan K, Merschhemke M, Kappos L; ASCLEPIOS I and ASCLEPIOS II Trial Groups.

N Engl J Med. 2020 Aug 6;383(6):546-557.

PMID: 32757523

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Role of Psychiatric, Cardiovascular, Socioeconomic, and Demographic Risk Factors on Idiopathic Normal Pressure Hydrocephalus: A Retrospective Case-Control Study

Ghaffari-Rafi A, Gorenflo R, Hu H, Viereck J, Liow K.
Clin Neurol Neurosurg. 2020 Jun;193:105836. Epub 2020 Apr 28.
PMID: 32371292

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Medical School Hotline: Hawai’i Pacific Neuroscience Summer Internship Program

Smith M, Wicknick A, Liow KK. Hawaii J Health Soc Welf. 2020 Mar 1;79(3):82-85.
PMID: 32190840

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Presentation of psychogenic nonepileptic seizures in Hawaii’s ethnoracially diverse population

Ho R, Ocol J, Lu C, Dolim S, Yang M, Carrazana E, Liow KK.
Epilepsy Behav. 2019 May 27;96:150-154
PMID:311461

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Zika Virus: Relevance to the State of Hawai’i

Lew WJ, Tsai WY, Balaraman V, Liow KK, Tyson J, Wang WK.
Hawaii J Med Public Health. 2019 Apr;78(4):123-127.
PMID: 30972234

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Inappropriate Laughter and Behaviours: How, What, and Why? Case of an Adult with Undiagnosed Gelastic Seizure with Hypothalamic Hamartoma

Beckwith NL, Khil JC, Teng J, Liow KK, Smith A, Luna J.
Hawaii J Med Public Health. 2018 Dec;77(12):319-324.
PMID: 30533284

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Hawaii Dementia Prevention Trial: A Randomized Trial Evaluating a Multifaceted Nutritional Intervention to Slow Cognitive Decline in Mild Cognitive Impairment Patients

Blake S, King G, Kerr N, Blake C, Harding T, Borman P, Moss K, Adapon P, Liow K, Journal of Brain Sciences, 2018 Conscientia Beam, vol. 2(1), pages 1-12

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Development Review of the BACE1 Inhibitor Lanabecestat (AZD3293/LY3314814)

Sims JR, Selzler KJ, Downing AM, Willis BA, Aluise CD, Zimmer J, Bragg S, Andersen S, Ayan-Oshodi M, Liffick E, Eads J, Wessels AM, Monk S, Schumi J, Mullen J.
PMID: 29181490

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Comparative Prediction of Nonepileptic Events Using MMPI-2 Clinical Scales, Harris Lingoes Subscales, and Restructured Clinical Scales.

Yamout KZ, Heinrichs RJ, Baade LE, Soetaert DK, Liow KK.
Epilepsy Behav. 2017 Mar;68:31-34. doi: 10.1016/j.yebeh.2016.12.008. Epub 2017 Jan 18. PMID:28109986

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National and International Presentations

Safety Profile of Valtoco® (diazepam nasal spray) in Patients with Epilepsy: Final Results From a Phase 3, Open-Label, 12-Month Repeat Dose Safety Study. Wheless JW, Sperling MR, Liow K, Vazquez B, Segal EB, Miller I, Hogan RE, Tarquinio D, Mauney W, DeSai J, Dlugos D, Biton V, Cascino G, Carrazana E; Rabinowicz AL, for the DIAZ.001.05 Study Group. American Managed Care Pharmacist (AMCP) Annual Meeting, Virtual. April 2021

 

 

Time to Second Doses in Emergency Seizure Patients Treated with Valtoco® (diazepam nasal spray) Across 24 Hours: Subgroup Results From a Completed Phase 3, Open-label, Repeat Dose Safety Study. Wheless JW, Sperling MR, Liow K, Vazquez B, Segal EB, Miller I, Hogan RE, Tarquinio D, Mauney W, DeSai J, Dlugos D, Biton V, Cascino G, Carrazana E; Rabinowicz AL, for the DIAZ.001.05 Study Group. American Managed Care Pharmacist (AMCP) Annual Meeting, Virtual. April 2021

  

Evaluation of Diazepam Nasal Spray in Patients with Epilepsy Concomitantly Using Maintenance Benzodiazepines: Interim Analysis from a Phase 3, Long-term, Open-label Safety Study. Segal E, Tarquinio D, Miller I, Wheless J, Dlugos D, Biton V, Cascino G, Desai J, Hogan E, Liow K, Mauney W, Sperling M, Cook D, Rabinowicz A, Carrazana E, for the DIAZ.001.05 Study Group. American Academy of Neurology (AAN), Annual Meeting, Virtual. April 2021

 

Safety Profile of Valtoco® (diazepam nasal spray) in Patients With Epilepsy: Final Results From a Phase 3, Open-Label, 12-Month Repeat Dose Safety Study. Wheless JW, Sperling MR, Liow K, Vazquez B, Segal EB, Miller I, Hogan RE, Tarquinio D, Mauney W, DeSai J, Dlugos D, Biton V, Cascino G, Carrazana E; Rabinowicz AL, for the DIAZ.001.05 Study Group. American Academy of Neurology (AAN), Annual Meeting, Virtual. April 2021

 

Time to Second Doses in Emergency Seizure Patients Treated with Valtoco® (diazepam nasal spray) Across 24 Hours: Subgroup Results From a Completed Phase 3, Open-label, Repeat Dose Safety Study. Wheless JW, Sperling MR, Liow K, Vazquez B, Segal EB, Miller I, Hogan RE, Tarquinio D, Mauney W, DeSai J, Dlugos D, Biton V, Cascino G, Carrazana E; Rabinowicz AL, for the DIAZ.001.05 Study Group. American Academy of Neurology (AAN), Annual Meeting, Virtual. April 2021

 

 

Use of a Second Dose of Diazepam Nasal Spray Within 4 Hours and Effect on the Safety Profile in Patients with Seizure Clusters: Interim Results from a Phase 3, Open-Label, 12-Month Repeat Dose Safety Study.  Daniel Tarquinio, Eric B. Segal, Ian Miller, James W. Wheless, R. Edward Hogan, Victor Biton, Gregory D. Cascino, Michael R. Sperling, Kore Liow, Blanca Vazquez, Ricardo Ayala, Weldon Mauney, Jay Desai, Adrian L. Rabinowicz, Enrique Carrazana, for the DIAZ.001.05 Study Group. 74th Annual Meeting of the American Epilepsy Society Meeting, Seattle, WA, Dec 2020.

 

Evaluation of Diazepam Nasal Spray in Patients with Epilepsy Concomitantly Using Maintenance Benzodiazepines: Interim Analysis from a Phase 3, Long-term, Open-label Safety Study.   Eric B. Segal, ; Daniel Tarquinio, Ian Miller, James W. Wheless, Dennis Dlugos, Ricardo Ayala,Victor Biton, Gregory D. Cascino, Jay Desai, R. Edward Hogan, Kore Liow, Weldon Mauney, Michael R. Sperling, Blanca Vazquez, David F. Cook, Adrian L. Rabinowicz, Enrique Carrazana for the DIAZ.001.05 Study Group. 74th Annual Meeting of the American Epilepsy Society Meeting, Seattle, WA, Dec 2020.

 

Efficacy and Safety Of Adjunctive Padsevonil In Adults With Drug-Resistant Focal Seizures: A Double-Blind, Randomized, Placebo-Controlled Dose-Finding Trial.  Rademacher M, Toledo M, Van Paesschen W, Liow K, Esch M, Webster E, Wang N, Werhahn K, French J. 74th Annual Meeting of the American Epilepsy Society Meeting, Seattle, WA, Dec 2020.

 

Vagal Nerve Stimulation (VNS) in genetic developmental epileptic encephalopathies (DEE):

approach in highly specialized centers around the world. Kwan P, Verner R, O’Brien T, El Tahry R, Keough K, Boggs J, Fahoum F, Greco T, Van Grunderbeek W, Sen A,Core-VNS Study Group. 2020 74th Annual Meeting of the American Epilepsy Society Meeting, Seattle, WA, Dec 2020.

 

CORE-VNS: A Prospective Outcomes Registry of Patients With Drug-resistant Epilepsy Treated With Vagus Nerve Stimulation Therapy.   Kwan P, Verner R, O’Brien T, El Tahry R, Keough K, Boggs J, Fahoum F, Greco T, Van Grunderbeek W, Sen A,Core-VNS Study Group. 2020 74th Annual Meeting of the American Epilepsy Society Meeting, Seattle, WA, Dec 2020.

 

A Randomized Phase 3 Study in Mild Alzheimer’s Disease (DAYBREAK-ALZ). Sims JR, Zimmer J, Wessels A, Selzler K, Andersen SW, Landry J, Mullen J, Barker P, Stern R, Vellas B, Boada M, Cohen S, MacSweeny E, Tariot P. Lanabecestat.  14th International Conference on Alzheimer’s and Parkinson’s Disease (ADPD) 2019.



Willis B, James D, Scott S, Bragg S, Mullen J, Downing A, Selzler K, Wessels A, Zimmer J, Sims J. Lanabecestat: Biomarker results from two Phase 3 studies in Alzheimer’s disease. 14th International Conference on Alzheimer’s and Parkinson’s Disease (ADPD) 2019.

 

Mintun M, Shcherbinin S, Charil A, Zimmer J, Andersen S, Landry J, Mullen J, Wessels A, Bragg S, Selzler K, Fleisher A, Sims J. Lanabecestat:  Neuroimaging results from two Phase 3 studies in Alzheimer’s disease. 14th International Conference on Alzheimer’s and Parkinson’s Disease (ADPD) 2019.

 

Two-Part, Double-Blind, Placebo-Controlled, Inpatient, Dose-Ranging Efficacy Study of Staccato Alprazolam (STAP-001) in Patients with Epilepsy with a Predictable Seizure Pattern: Results from the Initial Open-Label Feasibility Part.  J French, K Liow, B Vazquez, P Klein, D Tarquinio, B Reich, R Small, J Isojarvi. American Academy of Neurology Annual Meeting, Philadelphia, PA April, 2019

 

Pharmacokinetics of Diazepam Buccal Film in Adult Patients with Epilepsy: Comparison of Bioavailability with Periictal and Interictal Administration.  American Society of Experimental Therapeutics, Bethesda, MD, March 2019.

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