Publications
PubMed Peer Reviewed Publications and National
and International Presentations (Recent 2019-2021)
and International Presentations (Recent 2019-2021)
Student or Resident Led Projects
PubMed Peer Reviewed Publications
Early impact of the COVID-19 pandemic on outpatient Migraine care in Hawaii: Results of a quality improvement survey.
Smith M, Nakamoto M, Crocker J, Tiffany Morden F, Liu K, Ma E, Chong A, Van N, Vajjala V, Carrazana E, Viereck J, Liow K.
Headache. 2020 Dec 14;. doi: 10.1111/head.14030. PubMed PMID: 33316097
Epilepsy in the time of COVID-19.
Nakamoto M, Carrazana E, Viereck J, Liow K.
Acta Neurol Scand. 2020 Oct 11;. doi: 10.1111/ane.13360. PubMed PMID: 33043445; PubMed Central PMCID: PMC7675556
Role Of Psychiatric, Cardiovascular, Socioeconomic, And Demographic Risk Factors On Idiopathic Normal Pressure Hydrocephalus: A Retrospective Case-Control Study.
Ghaffari-Rafi A, Gorenflo R, Hu H, Viereck J, Liow K.
Clin Neurol Neurosurg. 2020 Jun;193:105836. doi: 10.1016/j.clineuro.2020.105836. Epub 2020 Apr 28. PubMed PMID: 32371292.
Medical School Hotline: Hawai’i Pacific Neuroscience Summer Internship Program.
Smith M, Wicknick A, Liow KK.
Hawaii J Health Soc Welf. 2020 Mar 1;79(3):82-85. PubMed PMID: 32190840; PubMed Central PMCID: PMC7061031
Presentation of psychogenic nonepileptic seizures in Hawaii’s ethnoracially diverse.
Ho R, Ocol J, Lu C, Dolim S, Yang M, Carrazana E, Liow KK.
Epilepsy Behav. 2019 Jul;96:150-154. doi: 10.1016/j.yebeh.2019.04.024. Epub 2019 May 28. PubMed PMID: 31146179.
Zika Virus: Relevance to the State of Hawai’i.
Lew WJ, Tsai WY, Balaraman V, Liow KK, Tyson J, Wang WK.
Hawaii J Med Public Health. 2019 Apr;78(4):123-127. PubMed PMID: 30972234; PubMed Central PMCID: PMC6452016.
Inappropriate Laughter and Behaviours: How, What, and Why? Case of an Adult with Undiagnosed Gelastic Seizure with Hypothalamic Hamartoma.
Beckwith NL, Khil JC, Teng J, Liow KK, Smith A, Luna J.
Hawaii J Med Public Health. 2018 Dec;77(12):319-324. PubMed PMID: 30533284; PubMed Central PMCID: PMC6277842.
Abstract
Sociodemographic Disparities and Risk Factors in Diagnosing Idiopathic Intracranial Hypertension: A Retrospective Case-Control Study.
Frances Morden Charissa Tan, Enrique Carrazana, Jason Viereck, Kore Kai Liow, Arash Ghaffari-Rafi.
J of Neurosurgery Supplements 2021
Assessing U.S. Demographic Recruitment Bias in 21st Century Neurosurgery Clinical Trials.
Taylor E, Buffenstein I, Kāneakua B, Ghaffari-Rafi A, Viereck J, Carrazana E, Liow K.
J of Neurosurgery Supplements 2021
Effectiveness of Dual Migraine therapy with CGRP Antagonists and OnabotulinumtoxinA Injections: Experience from a Single Migraine Center in Hawaii.
Lee J, Liang Y, Newman B, Tamanaha R, Toni T, Carrazana E, Vajjala V, Viereck J, Liow K.
Cephalgia 40 (IS), 2020 Pg. 104
COVID-19 Pandemic Effect on Epilepsy Outpatient Care at a Regional Referral Center in Hawaii.
Nakamoto M, Smith M, Crocker J, Morden F, Liu K, Ma E, Chong A, Van N, Mitchell C, Zhu E, Dang N, Carrazana E, Viereck J, Liow K.
Epilepsia Supplements December, 2020
Biopsychological predictors in patients with psychogenic non-epileptic seizures from a comprehensive epilepsy center in Hawai’i
C Lu, R Ho, J Ocol, M Yang, E Carrazana, K Liow,
Epilepsia Supplements December, 2019
Use of Cannabinoids in Patients with Epilepsy from a Comprehensive Epilepsy Center in Hawaii. R
Ho, J Zhang, C Lu, B Fong, K Oura, A Shipman, H Hu, A Appana, G Slattery, E Carrazana , K Liow,
Epilepsia Supplements December, 2019
Presentation of PNES in Hawaii’s Ethnoculturally Diverse Patients
Ocol J, Ho R, Lu C, Dolim S, Yang M, Kaplan A, Wilson C, Lee E, Carrazana E. Liow K. 2018
American Epilepsy Society Meeting, Epilepsia 2018.
Recent Student led National Publications
Early impact of the COVID-19 pandemic on outpatient Migraine care in Hawaii: Results of a quality improvement survey.
Smith M, Nakamoto M, Crocker J, Tiffany Morden F, Liu K, Ma E, Chong A, Van N, Vajjala V, Carrazana E, Viereck J, Liow K.
Headache. 2020 Dec 14;. doi: 10.1111/head.14030. PubMed PMID:
Epilepsy in the time of COVID-19.
Nakamoto M, Carrazana E, Viereck J, Liow K.
Acta Neurol Scand. 2020 Oct 11;. doi: 10.1111/ane.13360. PubMed PMID:
Role Of Psychiatric, Cardiovascular, Socioeconomic, And Demographic Risk Factors On Idiopathic Normal Pressure Hydrocephalus: A Retrospective Case-Control Study.
Ghaffari-Rafi A, Gorenflo R, Hu H, Viereck J, Liow K.
Clin Neurol Neurosurg. 2020 Jun;193:105836. doi: 10.1016/j.clineuro.2020.105836. Epub 2020 Apr 28. PubMed PMID:
Medical School Hotline: Hawai’i Pacific Neuroscience Summer Internship Program.
Smith M, Wicknick A, Liow KK.
Hawaii J Health Soc Welf. 2020 Mar 1;79(3):82-85. PubMed PMID:
Effectiveness of Dual Migraine therapy with CGRP Antagonists and OnabotulinumtoxinA Injections: Experience from a Single Migraine Center in Hawaii.
Lee J, Liang Y, Newman B, Tamanaha R, Toni T, Carrazana E, Vajjala V, Viereck J, Liow K.
Cephalgia 40 (IS), 2020 Pg. 104
COVID-19 Pandemic Effect on Epilepsy Outpatient Care at a Regional Referral Center in Hawaii.
Nakamoto M, Smith M, Crocker J, Morden F, Liu K, Ma E, Chong A, Van N, Mitchell C, Zhu E, Dang N, Carrazana E, Viereck J, Liow K.
Epilepsia Supplements December, 2020
National or International Presentations
Sociodemographic Disparities and Risk Factors in Diagnosing Idiopathic Intracranial Hypertension: A Retrospective Case-Control Study.
Frances Morden, Charissa Tan, Enrique Carrazana, Jason Viereck, Kore Kai Liow, Arash Ghaffari-Rafi.
American Association of Neurological Surgeons, Annual Scietific Meeting, Orlando, FL, August 2021
Assessing U.S. Demographic Recruitment Bias in 21st Century Neurosurgery Clinical Trials. Taylor E, Buffenstein I, Kāneakua B, Ghaffari-Rafi A, Viereck J, Carrazana E, Liow K. American Association of Neurological Surgeons, Annual Scientific Meeting, Orlando, FL, August 2021
Factors that Affect the Employability of Patients with Epilepsy in Hawaii: A Look at Race, Comorbidities, and Marital Status.
Gorenflo R, Kimball L, Taeza B, Gan A, Viereck J, Carrazana E, Liow K.
American Academy of Neurology Annual Meeting, April 2021
Effectiveness of Dual Migraine therapy with CGRP Antagonists and OnabotulinumtoxinA Injections: Experience from a Single Migraine Center in Hawaii.
Lee J, Liang Y, Newman B, Tamanaha R, Toni T, Carrazana E, Vajjala V, Viereck J, Liow K. 2020 International Headache Society Annual Meeting
COVID-19 Pandemic Effect on Epilepsy Outpatient Care at a Regional Referral Center in Hawaii.
Nakamoto M, Smith M, Crocker J, Morden F, Liu K, Ma E, Chong A, Van N, Mitchell C, Zhu E, Dang N, Carrazana E, Viereck J, Liow K.
74th Annual Meeting of the American Epilepsy Society Meeting, Seattle, WA, Dec 2020.
Use of Cannabinoids in Patients with Epilepsy from a Comprehensive Epilepsy Center in Hawaii.
R Ho, J Zhang, C Lu, B Fong, K Oura, A Shipman, H Hu, A Appana, G Slattery, E Carrazana, K Liow,
American Epilepsy Society Annual Meeting, Baltimore, MD, Dec, 2019
Biopsychological predictors in patients with psychogenic non-epileptic seizures from a comprehensive epilepsy center in Hawai’i,
C Lu, R Ho, J Ocol, M Yang, E Carrazana, K Liow
American Epilepsy Society Annual Meeting, Baltimore, MD, Dec, 2019
Recent Student Led Research Presented at National Meetings
Factors that Affect the Employability of Patients with Epilepsy in Hawaii: A Look at Race, Comorbidities, and Marital Status.
Gorenflo R, Kimball L, Taeza B, Gan A, Carrazana E, Liow K.
American Academy of Neurology Annual Meeting, April 2021
Effectiveness of Dual Migraine therapy with CGRP Antagonists and OnabotulinumtoxinA Injections: Experience from a Single Migraine Center in Hawaii.
Lee J, Liang Y, Newman B, Tamanaha R, Toni T, Carrazana E, Vajjala V, Viereck J, Liow K.
2020 International Headache Society Annual Meeting
COVID-19 Pandemic Effect on Epilepsy Outpatient Care at a Regional Referral Center in Hawaii.
Nakamoto M, Smith M, Crocker J, Morden F, Liu K, Ma E, Chong A, Van N, Mitchell C, Zhu E, Dang N, Carrazana E, Viereck J, Liow K.
74th Annual Meeting of the American Epilepsy Society Meeting, Seattle, WA, Dec 2020
Use of Cannabinoids in Patients with Epilepsy from a Comprehensive Epilepsy Center in Hawaii.
American Epilepsy Society Annual Meeting, Baltimore, MD, Dec, 2019
Biopsychological predictors in patients with psychogenic non-epileptic seizures from a comprehensive epilepsy center in Hawai’i,
American Epilepsy Society Annual Meeting, Baltimore, MD, Dec, 2019
Neuroscience Faculty Recent Research Work
PubMed Peer Reviewed Publications
Carrazana EJ.
Portrait of My Father: Frida Kahlo’s Intimate Relation to Epilepsy. Eur Neurol.
2021 May 19:1-5. doi: 10.1159/000516321. Epub ahead of print.
PMID: 34010835.
Online Full Text
Cascino GD, Tarquinio D, Wheless JW, Hogan RE, Sperling MR, Liow K, Desai J, Davis C, Rabinowicz AL, Carrazana E.
Lack of observed tolerance to diazepam nasal spray (Valtoco®) after long-term rescue therapy in patients with epilepsy: Interim results from a phase 3, open-label, repeat-dose safety study.
Epilepsy Behav. 2021 May 3;120:107983. doi: 10.1016/j.yebeh.2021.107983.
PubMed PMID: 33957437
Online Full Text PDF Link
Segal EB, Tarquinio D, Miller I, Wheless JW, Dlugos D, Biton V, Cascino GD, Desai J, Hogan RE, Liow K, Sperling MR, Vazquez B, Cook DF, Rabinowicz AL, Carrazana E.
Evaluation of diazepam nasal spray in patients with epilepsy concomitantly using maintenance benzodiazepines: An interim subgroup analysis from a phase 3, long-term, open-label safety study.
Epilepsia. 2021 May 4;. doi: 10.1111/epi.16901.
PubMed PMID: 33942315.
Open Access Online PDF
Nair DR, Laxer KD, Weber PB et al.
Nine-Year Prospective Efficacy And Safety Of Brain-Responsive Neurostimulation For Focal Epilepsy.
Neurology. 2020 Sep 1;95(9):e1244-e1256. doi: 10.1212/WNL.0000000000010154. Epub 2020 Jul 20.
PubMed PMID: 32690786; PubMed Central PMCID: PMC7538230.
Hauser SL, Bar-Or A, Cohen JA, Comi G, Correale J, Coyle PK, Cross AH, de Seze J, Leppert D, Montalban X, Selmaj K, Wiendl H, Kerloeguen C, Willi R, Li B, Kakarieka A, Tomic D, Goodyear A, Pingili R, Häring DA, Ramanathan K, Merschhemke M, Kappos L.
Ofatumumab versus Teriflunomide in Multiple Sclerosis.
N Engl J Med. 2020 Aug 6;383(6):546-557. doi: 10.1056/NEJMoa1917246.
PubMed PMID: 32757523.
Meador KJ, Pennell PB, May RC, Brown CA, Baker G, Bromley R, Loring DW, Cohen MJ.
Effects of periconceptional folate on cognition in children of women with epilepsy: NEAD study.
Neurology. 2020 Feb 18;94(7):e729-e740. doi: 10.1212/WNL.0000000000008757. Epub 2019 Dec 23.
PubMed PMID: 31871217; PubMed Central PMCID: PMC7176294.
Abstracts
Use of a Second Dose of Diazepam Nasal Spray Within 4 Hours and Effect on the Safety Profile in Patients with Seizure Clusters: Interim Results from a Phase 3, Open-Label, 12-Month Repeat Dose Safety Study.
Daniel Tarquinio, Eric B. Segal, Ian Miller, James W. Wheless, R. Edward Hogan, Victor Biton, Gregory D. Cascino, Michael R. Sperling, Kore Liow, Blanca Vazquez, Ricardo Ayala, Weldon Mauney, Jay Desai, Adrian L. Rabinowicz, Enrique Carrazana, for the DIAZ.001.05 Study Group.
Epilepsia Supplements December, 2020
Evaluation of Diazepam Nasal Spray in Patients with Epilepsy Concomitantly Using Maintenance Benzodiazepines: Interim Analysis from a Phase 3, Long-term, Open-label Safety Study.
Eric B. Segal, ; Daniel Tarquinio, Ian Miller, James W. Wheless, Dennis Dlugos, Ricardo Ayala,Victor Biton, Gregory D. Cascino, Jay Desai, R. Edward Hogan, Kore Liow, Weldon Mauney, Michael R. Sperling, Blanca Vazquez, David F. Cook, Adrian L. Rabinowicz, Enrique Carrazana for the DIAZ.001.05 Study Group.
Epilepsia Supplements December, 2020
Efficacy and Safety Of Adjunctive Padsevonil In Adults With Drug-Resistant Focal Seizures: A Double-Blind, Randomized, Placebo-Controlled Dose-Finding Trial.
Rademacher M, Toledo M, Van Paesschen W, Liow K, Esch M, Webster E, Wang N, Werhahn K, French J.
Epilepsia Supplements December, 2020
Vagal Nerve Stimulation (VNS) in genetic developmental epileptic encephalopathies (DEE): approach in highly specialized centers around the world.
Kwan P, Verner R, O’Brien T, El Tahry R, Keough K, Boggs J, Fahoum F, Greco T, Van Grunderbeek W, Sen A,Core-VNS Study Group.
Epilepsia Supplements December, 2020
CORE-VNS: A Prospective Outcomes Registry of Patients With Drug-resistant Epilepsy Treated With Vagus Nerve Stimulation Therapy.
Kwan P, Verner R, O’Brien T, El Tahry R, Keough K, Boggs J, Fahoum F, Greco T, Van Grunderbeek W, Sen A,Core-VNS Study Group. 2020.
Epilepsia Supplements December, 2020
Two-Part, Double-Blind, Placebo-Controlled, Inpatient, Dose-Ranging Efficacy Study of Staccato Alprazolam (STAP-001) in Patients with Epilepsy with a Predictable Seizure Pattern: Results from the Initial Open-Label Feasibility Part.
J French, K Liow, B Vazquez, P Klein, D Tarquinio, B Reich, R Small, J Isojarvi.
Neurology Supplements 2019
Wessels AM, Barbone JM, DiGregorio DT, Miller DS, Mullen JA, Sims JR. Lanabecestat: Rater performance and error characteristics of efficacy assessments in the DAYBREAK-ALZ study. CTAD Poster Abstract. J Prev Alzheimers Dis. 2018; 5(Supp 1):S188-S189.
Frank Nagy, Michael A. Rogawski, Hui Gong, Kore Liow, Sami Aboumater, Pavel Klein, Michael A. Gelfand, Cassie Jung, Stephen Wargacki, Rikin Mehta, Allen H. heller Pharmacokinetics of Diazepam Buccal Film in Adult Patients with Epilepsy: Comparison of Bioavailability with Periictal and Interictal Administration. Neurotherapeutics 2019.
Heller, T. Gong, K. Liow, S. Aboumatar, P. Klein, M. Gelfand, C. Jung, S. Wargacki, R. Mehta, M. Rogawski Pharmacokinetics of Diazepam Buccal Soluble Film in Adult Patients with Epilepsy. Epilepsia 2018.
C. Jung, J. Dubow, T. Gong, K. Liow, S. Aboumatar, P. Klein, M. Gelfand, S. Wargacki, R. Mehta, M. Rogawski, A. Heller. The Usability of Diazepam Buccal Soluble Film (DBSF) An Oral Treatment For The Management of Acute Bouts of Cluster Seizures In Adult Patients With Epilepsy. Epilepsia 2018.
Recent Neuroscience Faculty Research work at Clinical Research Center
Published or Presented Nationally
Published or Presented Nationally
Nair DR, Laxer KD, Weber PB et al. Nine-Year Prospective Efficacy And Safety Of Brain-Responsive Neurostimulation For Focal Epilepsy. Neurology.
Hauser SL, Bar-Or A, Cohen JA, Comi G, Correale J, Coyle PK, Cross AH, de Seze J, Leppert D, Montalban X, Selmaj K, Wiendl H, Kerloeguen C, Willi R, Li B, Kakarieka A, Tomic D, Goodyear A, Pingili R, Häring DA, Ramanathan K, Merschhemke M, Kappos L. Ofatumumab versus Teriflunomide in Multiple Sclerosis. N Engl J Med. 2020 Aug 6;383(6):546-557. doi: 10.1056/NEJMoa1917246. PubMed PMID: 32757523
Vagal Nerve Stimulation (VNS) in genetic developmental epileptic encephalopathies (DEE): approach in highly specialized centers around the world. Kwan P, Verner R, O’Brien T, El Tahry R, Keough K, Boggs J, Fahoum F, Greco T, Van Grunderbeek W, Sen A,Core-VNS Study Group. Epilepsia Supplements December, 2020
Use of a Second Dose of Diazepam Nasal Spray Within 4 Hours and Effect on the Safety Profile in Patients with Seizure Clusters: Interim Results from a Phase 3, Open-Label, 12-Month Repeat Dose Safety Study. Daniel Tarquinio, Eric B. Segal, Ian Miller, James W. Wheless, R. Edward Hogan, Victor Biton, Gregory D. Cascino, Michael R. Sperling, Kore Liow, Blanca Vazquez, Ricardo Ayala, Weldon Mauney, Jay Desai, Adrian L. Rabinowicz, Enrique Carrazana, for the DIAZ.001.05 Study Group. Epilepsia Supplements December, 2020
Efficacy and Safety Of Adjunctive Padsevonil In Adults With Drug-Resistant Focal Seizures: A Double-Blind, Randomized, Placebo-Controlled Dose-Finding Trial. Rademacher M, Toledo M, Van Paesschen W, Liow K, Esch M, Webster E, Wang N, Werhahn K, French J. Epilepsia Supplements December, 2020
Evaluation of Diazepam Nasal Spray in Patients with Epilepsy Concomitantly Using Maintenance Benzodiazepines: Interim Analysis from a Phase 3, Long-term, Open-label Safety Study. Eric B. Segal, ; Daniel Tarquinio, Ian Miller, James W. Wheless, Dennis Dlugos, Ricardo Ayala,Victor Biton, Gregory D. Cascino, Jay Desai, R. Edward Hogan, Kore Liow, Weldon Mauney, Michael R. Sperling, Blanca Vazquez, David F. Cook, Adrian L. Rabinowicz, Enrique Carrazana for the DIAZ.001.05 Study Group. Epilepsia Supplements December, 2020
CORE-VNS: A Prospective Outcomes Registry of Patients With Drug-resistant Epilepsy Treated With Vagus Nerve Stimulation Therapy. Kwan P, Verner R, O’Brien T, El Tahry R, Keough K, Boggs J, Fahoum F, Greco T, Van Grunderbeek W, Sen A,Core-VNS Study Group. 2020. Epilepsia Supplements December, 2020
Wessels AM, Barbone JM, DiGregorio DT, Miller DS, Mullen JA, Sims JR. Lanabecestat: Rater performance and error characteristics of efficacy assessments in the DAYBREAK-ALZ study. CTAD P
Two-Part, Double-Blind, Placebo-Controlled, Inpatient, Dose-Ranging Efficacy Study of Staccato Alprazolam (STAP-001) in Patients with Epilepsy with a Predictable Seizure Pattern: Results from the Initial Open-Label Feasibility Part. J French, K Liow, B Vazquez, P Klein, D Tarquinio, B Reich, R Small, J Isojarvi. Neurology Supplements 2019
Frank Nagy, Michael A. Rogawski, Hui Gong, Kore Liow, Sami Aboumater, Pavel Klein, Michael A. Gelfand, Cassie Jung, Stephen Wargacki, Rikin Mehta, Allen H. heller Pharmacokinetics of Diazepam Buccal Film in Adult Patients with Epileps
Safety Profile of Valtoco® (diazepam nasal spray) in Patients with Epilepsy: Final Results From a Phase 3, Open-Label, 12-Month Repeat Dose Safety Study. Wheless JW, Sperling MR, Liow K, Vazquez B, Segal EB, Miller I, Hogan RE, Tarquinio D, Mauney W, DeSai J, Dlugos D, Biton V, Cascino G, Carrazana E; Rabinowicz AL, for the DIAZ.001.05 Study Group. American Managed Care Pharmacist (AMCP) Annual Meeting, Virtual. April 2021
Time to Second Doses in Emergency Seizure Patients Treated with Valtoco® (diazepam nasal spray) Across 24 Hours: Subgroup Results From a Completed Phase 3, Open-label, Repeat Dose Safety Study. Wheless JW, Sperling MR, Liow K, Vazquez B, Segal EB, Miller I, Hogan RE, Tarquinio D, Mauney W, DeSai J, Dlugos D, Biton V, Cascino G, Carrazana E; Rabinowicz AL, for the DIAZ.001.05 Study Group. American Managed Care Pharmacist (AMCP) Annual Meeting, Virtual. April 2021
Evaluation of Diazepam Nasal Spray in Patients with Epilepsy Concomitantly Using Maintenance Benzodiazepines: Interim Analysis from a Phase 3, Long-term, Open-label Safety Study. Segal E, Tarquinio D, Miller I, Wheless J, Dlugos D, Biton V, Cascino G, Desai J, Hogan E, Liow K, Mauney W, Sperling M, Cook D, Rabinowicz A, Carrazana E, for the DIAZ.001.05 Study Group. American Academy of Neurology (AAN), Annual Meeting, Virtual. April 2021
Safety Profile of Valtoco® (diazepam nasal spray) in Patients With Epilepsy: Final Results From a Phase 3, Open-Label, 12-Month Repeat Dose Safety Study. Wheless JW, Sperling MR, Liow K, Vazquez B, Segal EB, Miller I, Hogan RE, Tarquinio D, Mauney W, DeSai J, Dlugos D, Biton V, Cascino G, Carrazana E; Rabinowicz AL, for the DIAZ.001.05 Study Group. American Academy of Neurology (AAN), Annual Meeting, Virtual. April 2021
Time to Second Doses in Emergency Seizure Patients Treated with Valtoco® (diazepam nasal spray) Across 24 Hours: Subgroup Results From a Completed Phase 3, Open-label, Repeat Dose Safety Study. Wheless JW, Sperling MR, Liow K, Vazquez B, Segal EB, Miller I, Hogan RE, Tarquinio D, Mauney W, DeSai J, Dlugos D, Biton V, Cascino G, Carrazana E; Rabinowicz AL, for the DIAZ.001.05 Study Group. American Academy of Neurology (AAN), Annual Meeting, Virtual. April 2021
Use of a Second Dose of Diazepam Nasal Spray Within 4 Hours and Effect on the Safety Profile in Patients with Seizure Clusters: Interim Results from a Phase 3, Open-Label, 12-Month Repeat Dose Safety Study. Daniel Tarquinio, Eric B. Segal, Ian Miller, James W. Wheless, R. Edward Hogan, Victor Biton, Gregory D. Cascino, Michael R. Sperling, Kore Liow, Blanca Vazquez, Ricardo Ayala, Weldon Mauney, Jay Desai, Adrian L. Rabinowicz, Enrique Carrazana, for the DIAZ.001.05 Study Group. 74th Annual Meeting of the American Epilepsy Society Meeting, Seattle, WA, Dec 2020.
Evaluation of Diazepam Nasal Spray in Patients with Epilepsy Concomitantly Using Maintenance Benzodiazepines: Interim Analysis from a Phase 3, Long-term, Open-label Safety Study. Eric B. Segal, ; Daniel Tarquinio, Ian Miller, James W. Wheless, Dennis Dlugos, Ricardo Ayala,Victor Biton, Gregory D. Cascino, Jay Desai, R. Edward Hogan, Kore Liow, Weldon Mauney, Michael R. Sperling, Blanca Vazquez, David F. Cook, Adrian L. Rabinowicz, Enrique Carrazana for the DIAZ.001.05 Study Group. 74th Annual Meeting of the American Epilepsy Society Meeting, Seattle, WA, Dec 2020.
Efficacy and Safety Of Adjunctive Padsevonil In Adults With Drug-Resistant Focal Seizures: A Double-Blind, Randomized, Placebo-Controlled Dose-Finding Trial. Rademacher M, Toledo M, Van Paesschen W, Liow K, Esch M, Webster E, Wang N, Werhahn K, French J. 74th Annual Meeting of the American Epilepsy Society Meeting, Seattle, WA, Dec 2020.
Vagal Nerve Stimulation (VNS) in genetic developmental epileptic encephalopathies (DEE):approach in highly specialized centers around the world. Kwan P, Verner R, O’Brien T, El Tahry R, Keough K, Boggs J, Fahoum F, Greco T, Van Grunderbeek W, Sen A,Core-VNS Study Group. 2020 74th Annual Meeting of the American Epilepsy Society Meeting, Seattle, WA, Dec 2020.
CORE-VNS: A Prospective Outcomes Registry of Patients With Drug-resistant Epilepsy Treated With Vagus Nerve Stimulation Therapy. Kwan P, Verner R, O’Brien T, El Tahry R, Keough K, Boggs J, Fahoum F, Greco T, Van Grunderbeek W, Sen A,Core-VNS Study Group. 2020 74th Annual Meeting of the American Epilepsy Society Meeting, Seattle, WA, Dec 2020.
A Randomized Phase 3 Study in
Use of Cannabinoids in Patients with Epilepsy from a Comprehensive Epilepsy Center in Hawaii. R Ho, J Zhang, C Lu, B Fong, K Oura, A Shipman, H Hu, A Appana, G Slattery, E Carrazana , K Liow, American Epilepsy Society Annual Meeting, Baltimore, MD, Dec, 2019
Biopsychological predictors in patients with psychogenic non-epileptic seizures from a comprehensive epilepsy center in Hawai’i, ,C Lu, R Ho, J Ocol, M Yang, E Carrazana, K Liow American Epilepsy Society Annual Meeting, Baltimore, MD, Dec, 2019
Willis B, James D, Scott S, Bragg S, Mullen J, Downing A, Selzler K, Wessels A, Zimmer J, Sims J. Lanabecestat: Biomarker results from two Phase 3 studies in Alzheimer’s disease. 14th International Conference on Alzheimer’s and Parkinson’s Disease (ADPD) 2019.
Mintun M, Shcherbinin S, Charil A, Zimmer J, Andersen S, Landry J, Mullen J, Wessels A, Bragg S, Selzler K, Fleisher A, Sims J. Lanabecestat: Neuroimaging re
Epilepsy in the time of COVID-19
Nakamoto M, Carranza E, Viereck J, Liow K. Epilepsy in the time of COVID-19.
Acta Neurol Scand. 2020;00:1-3
Ofatumumab versus Teriflunomide in Multiple Sclerosis
Hauser SL, Bar-Or A, Cohen JA, Comi G, Correale J, Coyle PK, Cross AH, de Seze J, Leppert D, Montalban X, Selmaj K, Wiendl H, Kerloeguen C, Willi R, Li B, Kakarieka A, Tomic D, Goodyear A, Pingili R, Häring DA, Ramanathan K, Merschhemke M, Kappos L; ASCLEPIOS I and ASCLEPIOS II Trial Groups.
N Engl J Med. 2020 Aug 6;383(6):546-557.
PMID: 32757523
Ghaffari-Rafi A, Gorenflo R, Hu H, Viereck J, Liow K.
Clin Neurol Neurosurg. 2020 Jun;193:105836. Epub 2020 Apr 28.
PMID: 32371292
Medical School Hotline: Hawai’i Pacific Neuroscience Summer Internship Program
Smith M, Wicknick A, Liow KK. Hawaii J Health Soc Welf. 2020 Mar 1;79(3):82-85.
PMID: 32190840
Presentation of psychogenic nonepileptic seizures in Hawaii’s ethnoracially diverse population
Ho R, Ocol J, Lu C, Dolim S, Yang M, Carrazana E, Liow KK.
Epilepsy Behav. 2019 May 27;96:150-154
PMID:311461
Zika Virus: Relevance to the State of Hawai’i
Lew WJ, Tsai WY, Balaraman V, Liow KK, Tyson J, Wang WK.
Hawaii J Med Public Health. 2019 Apr;78(4):123-127.
PMID: 30972234
Beckwith NL, Khil JC, Teng J, Liow KK, Smith A, Luna J.
Hawaii J Med Public Health. 2018 Dec;77(12):319-324.
PMID: 30533284
Blake S, King G, Kerr N, Blake C, Harding T, Borman P, Moss K, Adapon P, Liow K, Journal of Brain Sciences, 2018 Conscientia Beam, vol. 2(1), pages 1-12
Development Review of the BACE1 Inhibitor Lanabecestat (AZD3293/LY3314814)
Sims JR, Selzler KJ, Downing AM, Willis BA, Aluise CD, Zimmer J, Bragg S, Andersen S, Ayan-Oshodi M, Liffick E, Eads J, Wessels AM, Monk S, Schumi J, Mullen J.
PMID: 29181490
Yamout KZ, Heinrichs RJ, Baade LE, Soetaert DK, Liow KK.
Epilepsy Behav. 2017 Mar;68:31-34. doi: 10.1016/j.yebeh.2016.12.008. Epub 2017 Jan 18. PMID:28109986
National and International Presentations
Safety Profile of Valtoco® (diazepam nasal spray) in Patients with Epilepsy: Final Results From a Phase 3, Open-Label, 12-Month Repeat Dose Safety Study. Wheless JW, Sperling MR, Liow K, Vazquez B, Segal EB, Miller I, Hogan RE, Tarquinio D, Mauney W, DeSai J, Dlugos D, Biton V, Cascino G, Carrazana E; Rabinowicz AL, for the DIAZ.001.05 Study Group. American Managed Care Pharmacist (AMCP) Annual Meeting, Virtual. April 2021
Time to Second Doses in Emergency Seizure Patients Treated with Valtoco® (diazepam nasal spray) Across 24 Hours: Subgroup Results From a Completed Phase 3, Open-label, Repeat Dose Safety Study. Wheless JW, Sperling MR, Liow K, Vazquez B, Segal EB, Miller I, Hogan RE, Tarquinio D, Mauney W, DeSai J, Dlugos D, Biton V, Cascino G, Carrazana E; Rabinowicz AL, for the DIAZ.001.05 Study Group. American Managed Care Pharmacist (AMCP) Annual Meeting, Virtual. April 2021
Evaluation of Diazepam Nasal Spray in Patients with Epilepsy Concomitantly Using Maintenance Benzodiazepines: Interim Analysis from a Phase 3, Long-term, Open-label Safety Study. Segal E, Tarquinio D, Miller I, Wheless J, Dlugos D, Biton V, Cascino G, Desai J, Hogan E, Liow K, Mauney W, Sperling M, Cook D, Rabinowicz A, Carrazana E, for the DIAZ.001.05 Study Group. American Academy of Neurology (AAN), Annual Meeting, Virtual. April 2021
Safety Profile of Valtoco® (diazepam nasal spray) in Patients With Epilepsy: Final Results From a Phase 3, Open-Label, 12-Month Repeat Dose Safety Study. Wheless JW, Sperling MR, Liow K, Vazquez B, Segal EB, Miller I, Hogan RE, Tarquinio D, Mauney W, DeSai J, Dlugos D, Biton V, Cascino G, Carrazana E; Rabinowicz AL, for the DIAZ.001.05 Study Group. American Academy of Neurology (AAN), Annual Meeting, Virtual. April 2021
Time to Second Doses in Emergency Seizure Patients Treated with Valtoco® (diazepam nasal spray) Across 24 Hours: Subgroup Results From a Completed Phase 3, Open-label, Repeat Dose Safety Study. Wheless JW, Sperling MR, Liow K, Vazquez B, Segal EB, Miller I, Hogan RE, Tarquinio D, Mauney W, DeSai J, Dlugos D, Biton V, Cascino G, Carrazana E; Rabinowicz AL, for the DIAZ.001.05 Study Group. American Academy of Neurology (AAN), Annual Meeting, Virtual. April 2021
Use of a Second Dose of Diazepam Nasal Spray Within 4 Hours and Effect on the Safety Profile in Patients with Seizure Clusters: Interim Results from a Phase 3, Open-Label, 12-Month Repeat Dose Safety Study. Daniel Tarquinio, Eric B. Segal, Ian Miller, James W. Wheless, R. Edward Hogan, Victor Biton, Gregory D. Cascino, Michael R. Sperling, Kore Liow, Blanca Vazquez, Ricardo Ayala, Weldon Mauney, Jay Desai, Adrian L. Rabinowicz, Enrique Carrazana, for the DIAZ.001.05 Study Group. 74th Annual Meeting of the American Epilepsy Society Meeting, Seattle, WA, Dec 2020.
Evaluation of Diazepam Nasal Spray in Patients with Epilepsy Concomitantly Using Maintenance Benzodiazepines: Interim Analysis from a Phase 3, Long-term, Open-label Safety Study. Eric B. Segal, ; Daniel Tarquinio, Ian Miller, James W. Wheless, Dennis Dlugos, Ricardo Ayala,Victor Biton, Gregory D. Cascino, Jay Desai, R. Edward Hogan, Kore Liow, Weldon Mauney, Michael R. Sperling, Blanca Vazquez, David F. Cook, Adrian L. Rabinowicz, Enrique Carrazana for the DIAZ.001.05 Study Group. 74th Annual Meeting of the American Epilepsy Society Meeting, Seattle, WA, Dec 2020.
Efficacy and Safety Of Adjunctive Padsevonil In Adults With Drug-Resistant Focal Seizures: A Double-Blind, Randomized, Placebo-Controlled Dose-Finding Trial. Rademacher M, Toledo M, Van Paesschen W, Liow K, Esch M, Webster E, Wang N, Werhahn K, French J. 74th Annual Meeting of the American Epilepsy Society Meeting, Seattle, WA, Dec 2020.
Vagal Nerve Stimulation (VNS) in genetic developmental epileptic encephalopathies (DEE):
approach in highly specialized centers around the world. Kwan P, Verner R, O’Brien T, El Tahry R, Keough K, Boggs J, Fahoum F, Greco T, Van Grunderbeek W, Sen A,Core-VNS Study Group. 2020 74th Annual Meeting of the American Epilepsy Society Meeting, Seattle, WA, Dec 2020.
CORE-VNS: A Prospective Outcomes Registry of Patients With Drug-resistant Epilepsy Treated With Vagus Nerve Stimulation Therapy. Kwan P, Verner R, O’Brien T, El Tahry R, Keough K, Boggs J, Fahoum F, Greco T, Van Grunderbeek W, Sen A,Core-VNS Study Group. 2020 74th Annual Meeting of the American Epilepsy Society Meeting, Seattle, WA, Dec 2020.
A Randomized Phase 3 Study in Mild Alzheimer’s Disease (DAYBREAK-ALZ). Sims JR, Zimmer J, Wessels A, Selzler K, Andersen SW, Landry J, Mullen J, Barker P, Stern R, Vellas B, Boada M, Cohen S, MacSweeny E, Tariot P. Lanabecestat. 14th International Conference on Alzheimer’s and Parkinson’s Disease (ADPD) 2019.
Willis B, James D, Scott S, Bragg S, Mullen J, Downing A, Selzler K, Wessels A, Zimmer J, Sims J. Lanabecestat: Biomarker results from two Phase 3 studies in Alzheimer’s disease. 14th International Conference on Alzheimer’s and Parkinson’s Disease (ADPD) 2019.
Mintun M, Shcherbinin S, Charil A, Zimmer J, Andersen S, Landry J, Mullen J, Wessels A, Bragg S, Selzler K, Fleisher A, Sims J. Lanabecestat: Neuroimaging results from two Phase 3 studies in Alzheimer’s disease. 14th International Conference on Alzheimer’s and Parkinson’s Disease (ADPD) 2019.
Two-Part, Double-Blind, Placebo-Controlled, Inpatient, Dose-Ranging Efficacy Study of Staccato Alprazolam (STAP-001) in Patients with Epilepsy with a Predictable Seizure Pattern: Results from the Initial Open-Label Feasibility Part. J French, K Liow, B Vazquez, P Klein, D Tarquinio, B Reich, R Small, J Isojarvi. American Academy of Neurology Annual Meeting, Philadelphia, PA April, 2019
Pharmacokinetics of Diazepam Buccal Film in Adult Patients with Epilepsy: Comparison of Bioavailability with Periictal and Interictal Administration. American Society of Experimental Therapeutics, Bethesda, MD, March 2019.
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