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- Call or text: +1 (808) 261-4476
- Mon-Fri (8:30am - 4:30pm) Lunch Break 12:30pm-1:30pm
- [email protected]
Buffenstein I, Kaneakua B, Taylor E, Matsunaga M, Choi SY, Carrazana E, Viereck J, Liow KK, Ghaffari-Rafi A. Demographic recruitment bias of adults in United States randomized clinical trials by disease categories between 2008 to 2019: a systematic review and meta-analysis. Nature Sci Rep. 2023 Jan 2;13(1):42. doi: 10.1038/s41598-022-23664-1. PubMed PMID: 36593228; PubMed Central PMCID: PMC9807581.
Chang BK, Adlawan J, Fesenmeier S, Kaminskas D, Carrazana E, Liow KK. A Rare Presentation of Central Nervous System Tuberculomas in an Immunocompetent Patient. Hawaii J Health Soc Welf. 2022 Jun;81(6):151-154. PMID: 35673365; PMCID: PMC9168935.
Cori Xiu Yue Sutton, Enrique Carrazana, Catherine Mitchell, Jason Viereck, Kore Kai Liow, Arash Ghaffari-Rafi, Identification of associations and distinguishing moyamoya disease from ischemic strokes of other etiologies: A retrospective case-control study, Annals of Medicine and Surgery, Volume 78,2022,103771, ISSN 2049-0801, https://doi.org/10.1016/j.amsu.2022.103771
Gorenflo R, Ho R, Carrazana E, Mitchell C, Viereck J, Liow KK, Ghaffari-Rafi A. Identification of risk factors and distinguishing psychogenic nonepileptic seizures from epilepsy: A retrospective case-control study. Clin Neurol Neurosurg. 2022 Mar 31;217:107221. doi: 10.1016/j.clineuro.2022.107221. Epub ahead of print. PMID: 35429851.
Ogasawara R, Kang E, Among J, Oyadomari K, Capitaine J, Regaspi N, Borman P, Viereck J, Carrazana E, Liow KK. Native Hawaiian and other pacific islanders’ leading risk factors for ischemic stroke: A comparative ethnographic study. J Stroke Cerebrovasc Dis. 2022 Mar 24;31(6):106433. doi: 10.1016/j.jstrokecerebrovasdis.2022.106433. PMID: 35339856
Crocker J, Liu K, Smith M, Nakamoto M, Mitchell C, Zhu E, Ma E, Morden FT, Chong A, Van N, Dang N, Borman P, Carrazana E, Viereck J, Liow KK. Early Impact of the COVID-19 Pandemic on Outpatient Neurologic Care in Hawai’i. Hawaii J Health Soc Welf. 2022 Jan;81(1):6-12. PMID: 35028589; PMCID: PMC8742305.
Ghaffari-Rafi A, Teehera KB, Higashihara TJ, Morden FTC, Goo C, Pang M, Sutton CXY, Kim KM, Lew RJ, Luu K, Yamashita S, Mitchell C, Carrazana E, Viereck J, Liow KK. Variables Associated with Coronavirus Disease 2019 Vaccine Hesitancy Amongst Patients with Neurological Disorders. Infect Dis Rep. 2021 Aug 30;13(3):763-810. doi: 10.3390/idr13030072. PMID: 34562997; PMCID: PMC8482072.
Smith M, Van N, Roberts A, Hosaka KRJ, Choi SY, Viereck J, Carrazana E, Borman P, Chen JJ, Liow KK. Disparities in Alzheimer Disease and Mild Cognitive Impairment Among Native Hawaiians and Pacific Islanders. Cogn Behav Neurol. 2021 Sep 2;34(3):200-206. doi: 10.1097/WNN.0000000000000279.
PubMed PMID: 34473671.
Morden FTC, Tan C, Carrazana E, Viereck J, Liow KK, Ghaffari-Rafi A. Characterizing idiopathic intracranial hypertension socioeconomic disparities and clinical risk factors: A retrospective case-control study. Clin Neurol Neurosurg. 2021 Aug 14;208:106894
PMID: 34455402.
Toni T, Tamanaha R, Newman B, Liang Y, Lee J, Carrazana E, Vajjala V, Viereck J, Liow KK. Effectiveness of dual migraine therapy with CGRP inhibitors and onabotulinumtoxinA injections: case series. Neurol Sci. 2021 Aug 18.doi: 10.1007/s10072-021-05547-x.
PMID: 34409517 https://link.springer.com/article/10.1007%2Fs10072-021-05547-x
Ko AWK, Ghaffari-Rafi A, Chan A, Harris WB, Imasa A, Liow KK, Viereck J. A Case Report of Antibiotic-Induced Aseptic Meningitis in Psoriasis. Hawaii J Health Soc Welf. 2021 Jun;80(6):129-133.
PubMed PMID: 34195619; PubMed Central PMCID: PMC8237324.Online PDF Access
Smith M, Nakamoto M, Crocker J, Tiffany Morden F, Liu K, Ma E, Chong A, Van N, Vajjala V, Carrazana E, Viereck J, Liow K. Early impact of the COVID-19 pandemic on outpatient migraine care in Hawaii: Results of a quality improvement survey. Headache. 2020 Dec 14;. doi: 10.1111/head.14030.
PubMed PMID: 33316097.
Nakamoto M, Carrazana E, Viereck J, Liow K. Epilepsy in the time of COVID-19. Acta Neurol Scand. 2020 Oct 11;. doi: 10.1111/ane.13360. [Epub ahead of print]
PubMed PMID: 33043445; PubMed Central PMCID: PMC7675556.
Ghaffari-Rafi A, Gorenflo R, Hu H, Viereck J, Liow K. Role Of Psychiatric, Cardiovascular, Socioeconomic, And Demographic Risk Factors On Idiopathic Normal Pressure Hydrocephalus: A Retrospective Case-Control Study. Clin Neurol Neurosurg. 2020 Jun;193:105836. doi: 10.1016/j.clineuro.2020.105836. Epub 2020 Apr 28.
PubMed PMID: 32371292.
Smith M, Wicknick A, Liow KK. Medical School Hotline: Hawai’i Pacific Neuroscience Summer Internship Program. Hawaii J Health Soc Welf. 2020 Mar 1;79(3):82-85. PubMed PMID: 32190840; PubMed Central PMCID: PMC7061031.
Ho R, Ocol J, Lu C, Dolim S, Yang M, Carrazana E, Liow KK. Presentation of psychogenic nonepileptic seizures in Hawaii’s ethnoracially diverse population. Epilepsy Behav. 2019 Jul;96:150-154. doi: 10.1016/j.yebeh.2019.04.024. Epub 2019 May 28.
PubMed PMID: 31146179
Lew WJ, Tsai WY, Balaraman V, Liow KK, Tyson J, Wang WK. Zika Virus: Relevance to the State of Hawai’i. Hawaii J Med Public Health. 2019 Apr;78(4):123-127.
PubMed PMID: 30972234; PubMed Central PMCID: PMC6452016.
Beckwith NL, Khil JC, Teng J, Liow KK, Smith A, Luna J. Inappropriate Laughter and Behaviours: How, What, and Why? Case of an Adult with Undiagnosed Gelastic Seizure with Hypothalamic Hamartoma. Hawaii J Med Public Health. 2018 Dec;77(12):319-324. PubMed PMID: 30533284; PubMed Central PMCID: PMC6277842.
Impact of Return-to-Exercise on Traumatic Brain Injury Recovery in a Community Setting
Edward Weldon, Ryan Nakamura, Tracy Van, Ana Nakamura, Chancen Law, Connor Goo, Meliza Roman, Enrique Carrazana, Jason Viereck, Kore Liow. American Academy of Neurology (AAN) 2023 Annual Meeting, April 2023, Boston, MA
Barriers To Alzheimer’s Disease Clinical Trial Participation in Hawaii’s Minority-Majority Population. Anson Y Lee, Julia R Jahansooz, Darrell Guittu, Rexton Suzuki, Lauren Pak, Kyle M Ishikawa, Connor Goo, John J Chen, Enrique Carrazana , Jason Viereck, Kore K Liow. 2023 ADPD Advances in Science & Therapy. March 2023, Gothenburg, Sweden.
Evaluating Whether EEG Could Predict Alzheimer’s Disease Onset in Preclinical Patients with the ApoE4 Allele: An Update. Kim N, Tan C, Ma E, Kutlu S, Mitchell C, Carrazana E, Viereck J, Vajjala V, Liow K. 2022 American Epilepsy Society Meeting, Nashville, TN December 2022
Employability, Work Difficulties and Factors Impacting Chronic Migraine Patients of Hawaii: Results of a Quality Improvement Survey, Michelle Stafford, Tracy Van, Rachel Gorenflo, Frances Morden, Kara Ushijima, Ashley Ung, Emma Inouye, Uiyeol Yoon, Dr. Vimala Vajjala, Dr. Enrique Carrazana, Dr. Kore Liow. American Academy of Neurology Annual Meeting, Seattle, WA, April 2022.
Influence of Ethnoracial and Sociodemographic Variables on Incidence and Management of Traumatic Brain Injury Patients in Hawaii. Kayti Luu, Michelle Pang, Rachel Gorenflo, Frances Morden, Ariel Ma, Nicholas Sims, Lauren Fujii, Kent Yamamoto, Enrique Carrazana, Jason Viereck, Kore Liow, American Academy of Neurology Annual Meeting, Seattle, WA, April 2022.
Association of Mechanism of Injury and Clinical Presentation of Patients with Traumatic Brain Injury in Hawai’i. Michelle Pang, Kayti Luu, Frances Morden, Rachel Gorenflo, Ariel Ma1, Nicholas Sims, Lauren Fujii, Kent Yamamoto, Enrique Carrazana, Jason Viereck, Kore Kai Liow. American Association of Neurological Surgeons (AANS) Annual Scientific Meeting,
Philadelphia, PA, USA. April 2022.
Identifying Familiarity and Knowledge Of Aducanumab In Caregivers Of Hawaii Alzheimerʼs Disease Patients. C. Goo, F. Morden, S. Aquino, K. Wong, J. Kawamura, S. Masca, R. Gorenflo , P. Borman, E. Carrazana, J. Viereck, K. Liow. 16th International Conference on Alzheimer’s & Parkinson’s Diseases, Barcelona, Spain. March 15-20, 2022
Systematic Review of Recruitment Bias in U.S. Phase 2 and 3 Randomized Clinical Trials of Cancer & Chemotherapy in Adults: 2008-2019. Buffenstein, I, Taylor E, Kāneakua, B, Matsunaga, M., Choi SY, Carrazana E, Liow, K, Viereck,J, Ghaffari-Rafi A. International Cancer Education Conference, Virtual, October 12-16, 2021
Buffenstein I., Tan C., Linna J., Masca A., Kayumova R., Ragheb J., Gorenflo R., Chang J., Carrazana E., Viereck J., Morden F., Liow K. “Sociodemographic Disparities of Patients with Lumbar Radiculopathy: A Single-Centered Retrospective Study.” 2022 Association of Academic Physiatrists Annual Scientific Meeting, New Orleans, Feb 2022.
Sociodemographic and Biological Differences Between Traumatic Brain Injury Patients Of Different Ethnoracial Groups Michelle Pang, Kayti Luu, Rachel Gorenflo, Frances Morden, Ariel Ma, Nicholas Sims, Lauren Fujii, Kent Yamamoto, Enrique Carrazana, Jason Viereck, Kore Kai Liow. 2022 Association of Academic Physiatrists Annual Scientific Meeting, New Orleans, Feb 2022.
Evaluating Whether EEG could Predict Alzheimer’s Disease Onset in Preclinical Patients with the ApoE4 Allele Ma E, Kutlu S, Kim N, Mitchell C, Vajjala V, Carrazana E, Viereck J, Liow K 2021 AAIC (Alzheimer’s Association International Conference), Denver, CO, Wednesday 2021 July 26th
Demographic Bias in Opioid Use Disorder Clinical Trials. Buffenstein, I, Taylor E, Kāneakua, B, Carrazana E, Liow, K, Viereck,J, Ghaffari-Rafi A. American Medical Association Research Challenge. Virtual Conference, December 2021
Psychiatric, and Biological Risk Factors in Psychogenic Nonepileptic Seizures. Gorenflo R, Ho R, Viereck J, Mitchell C, Carrazana E, Liow KK, Ghaffari-Rafi A, Identifying Socioeconomic, 25th World Congress of Neurology. Annual Scientific Meeting, Rome, Italy. October 3-7, 2021
Comparing Epilepsy to Psychogenic Non-Epileptic Seizures, Identification of Risk Factors: A Retrospective Case-Control Study. Ho R, Gorenflo R, Viereck J, Mitchell C, Carrazana E, Liow KK, Ghaffari-Rafi. 25th World Congress of Neurology. Annual Scientific Meeting, Rome, Italy. October 3-7, 2021
Sociodemographic Disparities and Risk Factors in Diagnosing Idiopathic Intracranial
Hypertension: A Retrospective Case-Control Study. Frances Morden Charissa Tan, Enrique Carrazana, Jason Viereck, Kore Kai Liow, Arash Ghaffari-Rafi. American Association of Neurological Surgeons, Annual Scietific Meeting, Orlando, FL, August 2021
Assessing U.S. Demographic Recruitment Bias in 21st Century Neurosurgery Clinical Trials. Taylor E, Buffenstein I, Kāneakua B, Ghaffari-Rafi A, Viereck J, Carrazana E, Liow K. American Association of Neurological Surgeons, Annual Scientific Meeting, Orlando, FL, August 2021
Factors that Affect the Employability of Patients with Epilepsy in Hawaii: A Look at Race, Comorbidities, and Marital Status. Gorenflo R, Kimball L, Taeza B, Gan A, Viereck J, Carrazana E, Liow K. American Academy of Neurology Annual Meeting, April 2021
Effectiveness of Dual Migraine therapy with CGRP Antagonists and OnabotulinumtoxinA Injections: Experience from a Single Migraine Center in Hawaii. Lee J, Liang Y, Newman B, Tamanaha R, Toni T, Carrazana E, Vajjala V, Viereck J, Liow K. 2020 International Headache Society Annual Meeting
COVID-19 Pandemic Effect on Epilepsy Outpatient Care at a Regional Referral Center in Hawaii. Nakamoto M, Smith M, Crocker J, Morden F, Liu K, Ma E, Chong A, Van N, Mitchell C, Zhu E, Dang N, Carrazana E, Viereck J, Liow K. 74th Annual Meeting of the American Epilepsy Society Meeting, Seattle, WA, Dec 2020.
Use of Cannabinoids in Patients with Epilepsy from a Comprehensive Epilepsy Center in Hawaii. R Ho, J Zhang, C Lu, B Fong, K Oura, A Shipman, H Hu, A Appana, G Slattery, E Carrazana , K Liow, American Epilepsy Society Annual Meeting, Baltimore, MD, Dec, 2019
Biopsychological predictors in patients with psychogenic non-epileptic seizures from a comprehensive epilepsy center in Hawai’i, ,C Lu, R Ho, J Ocol, M Yang, E Carrazana, K Liow American Epilepsy Society Annual Meeting, Baltimore, MD, Dec, 2019
Presentation of PNES in Hawaii’s Ethnoculturally Diverse Patients. American Epilepsy Society Meeting, New Orleans, LA. December 2018.
Fang, C., Hernandez, P., Liow, K. et al. Buntanetap, a Novel Translational Inhibitor of Multiple Neurotoxic Proteins, Proves to Be Safe and Promising in Both Alzheimer’s and Parkinson’s Patients. J Prev Alzheimers Dis (2022). https://doi.org/10.14283/jpad.2022.84
French, J, Biton, V, Dave, H, Detyniecki, K, Gelfand, MA, Gong, H, Liow K et al. A randomized phase 2b efficacy study in patients with seizure episodes with a predictable pattern using Staccato® alprazolam for rapid seizure termination. Epilepsia. 2022; 00: 1– 12. https://onlinelibrary.wiley.com/doi/epdf/10.1111/epi.17441
Liow KK, Viereck J. COVID-19 Is Changing Our Understanding of the Neuroscience of Viral Infections: What We Can Do to Prepare for the Future?. Neurol Int. 2022 Jan 6;14(1):89. doi: 10.3390/neurolint14010007. PubMed PMID: 35076582; PubMed Central PMCID: PMC8788498.
Rademacher, M, Toledo, M, Van Paesschen, W, Liow, KK, Milanov, IG, Esch, M-L, et al. Efficacy and safety of adjunctive padsevonil in adults with drug-resistant focal epilepsy: Results from two double-blind, randomized, placebo-controlled trials. Epilepsia Open. 2022; 00: 1– 13. https://doi.org/10.1002/epi4.12656
Sperling MR, Wheless JW, Hogan RE, Dlugos D, Cascino GD, Liow K, Rabinowicz AL, Carrazana E; DIAZ 001.05 Study Group. Use of second doses of Valtoco® (diazepam nasal spray) across 24 hours after the initial dose for out-of-hospital seizure clusters: Results from a phase 3, open-label, repeat-dose safety study. Epilepsia. 2022 Apr;63(4):836-843. doi: 10.1111/epi.17177. Epub 2022 Feb 2. PMID: 35112342.
Mignot E, Mayleben D, Fietze I, Leger D, Zammit G, Bassetti CLA, Pain S, Kinter DS, Roth T; investigators. Safety And Efficacy Of Daridorexant In Patients With Insomnia Disorder: Results From Two Multicentre, Randomised, Double-Blind, Placebo-Controlled, Phase 3 Trials. Lancet Neurol. 2022 Feb;21(2):125-139. doi: 10.1016/S1474-4422(21)00436-1. Erratum in: Lancet Neurol. 2022 Jan 20;:
PMID: 35065036.
French JA, Cole AJ, Faught E, Theodore WH, Vezzani A, Liow K, Halford JJ, Armstrong R, Szaflarski JP, Hubbard S, Patel J, Chen K, Feng W, Rizzo M, Elkins J, Knafler G, Parkerson KA; OPUS Study Group. Safety and Efficacy of Nataluzimab as Adjunctive Therapy for People With Drug-Resistant Epilepsy: A Phase 2 Study. Neurology. 2021 Sep 14:10.1212/
PMID: 34521687.
Wheless JW, Miller I, Hogan RE, Dlugos D, Biton V, Cascino GD, Sperling MR, Liow K, Vazquez B, Segal EB, Tarquinio D, Mauney W, Desai J, Rabinowicz AL, Carrazana E; DIAZ.001.05 Study Group. Final results from a Phase 3, long-term, open-label, repeat-dose safety study of diazepam nasal spray for seizure clusters in patients with epilepsy. Epilepsia. 2021 Aug 21. doi: 10.1111/epi.17041.
PMID: 34418086. https://onlinelibrary.wiley.com/doi/epdf/10.1111/epi.17041
Cascino GD, Tarquinio D, Wheless JW, Hogan RE, Sperling MR, Liow K, Desai J, Davis C, Rabinowicz AL, Carrazana E. Lack of observed tolerance to diazepam nasal spray (Valtoco®) after long-term rescue therapy in patients with epilepsy: Interim results from a phase 3, open-label, repeat-dose safety study. Epilepsy Behav. 2021 May 3;120:107983. doi: 10.1016/j.yebeh.2021.107983
PubMed PMID: 33957437 Online Full Text PDF Link
Segal EB, Tarquinio D, Miller I, Wheless JW, Dlugos D, Biton V, Cascino GD, Desai J, Hogan RE, Liow K, Sperling MR, Vazquez B, Cook DF, Rabinowicz AL, Carrazana E. Evaluation of diazepam nasal spray in patients with epilepsy concomitantly using maintenance benzodiazepines: An interim subgroup analysis from a phase 3, long-term, open-label safety study. Epilepsia. 2021 May 4;. doi: 10.1111/epi.16901.
PubMed PMID: 33942315. Open Access Online PDF
Miller I, Wheless JW, Hogan RE, Dlugos D, Biton V, Cascino GD, Sperling MR, Liow K, Vazquez B, Segal EB, Tarquinio D, Mauney W, Desai J, Rabinowicz AL, Carrazana E. Consistent safety and tolerability of Valtoco® (diazepam nasal spray) in relationship to usage frequency in patients with seizure clusters: Interim results from a phase 3, long-term, open-label, repeat-dose safety study. Epilepsia Open. 2021 May 5;. doi: 10.1002/epi4.12494. Online Access
PubMed PMID: 34033266
Nair DR, Laxer KD, Weber PB et al. Nine-Year Prospective Efficacy And Safety Of Brain-Responsive Neurostimulation For Focal Epilepsy. Neurology. 2020 Sep 1;95(9):e1244-e1256. doi: 10.1212/WNL.0000000000010154. Epub 2020 Jul 20.
PubMed PMID: 32690786; PubMed Central PMCID: PMC7538230.
Hauser SL, Bar-Or A, Cohen JA, Comi G, Correale J, Coyle PK, Cross AH, de Seze J, Leppert D, Montalban X, Selmaj K, Wiendl H, Kerloeguen C, Willi R, Li B, Kakarieka A, Tomic D, Goodyear A, Pingili R, Häring DA, Ramanathan K, Merschhemke M, Kappos L. Ofatumumab versus Teriflunomide in Multiple Sclerosis. N Engl J Med. 2020 Aug 6;383(6):546-557. doi: 10.1056/NEJMoa1917246.
PubMed PMID: 32757523.
Meador KJ, Pennell PB, May RC, Brown CA, Baker G, Bromley R, Loring DW, Cohen MJ. Effects of periconceptional folate on cognition in children of women with epilepsy: NEAD study. Neurology. 2020 Feb 18;94(7):e729-e740. doi: 10.1212/WNL.0000000000008757. Epub 2019 Dec 23. PubMed PMID: 31871217; PubMed Central PMCID: PMC7176294.
Safety and Time to Second Doses in Pediatric and Adult Patients With Seizure Clusters Treated With Diazepam Nasal Spray in a Phase 3, Open-Label, Repeat-Dose Safety Study. James W. Wheless, R. Edward Hogan, Michael R. Sperling, Kore Liow, Daniel Tarquinio, Jay Desai, Dennis Dlugos, Gregory D. Cascino, Enrique Carrazana, and Adrian L. Rabinowicz, for the DIAZ.001.05 Study Group. 2nd North American Epilepsy Congress, May 2022
Timing to Administration and Ease of Dosing of Diazepam Nasal Spray Rescue Therapy for Seizure Clusters: Results from a Phase 3, Long-Term Open-Label, Repeat-Dose Safety Study. Jay Desai, MD; R. Edward Hogan, MD; James W. Wheless, MD; Michael R. Sperling, MD; Kore Liow, MD; Daniel Tarquinio; Dennis Dlugos, MD; Gregory D. Cascino, MD; Sunita N. Misra, MD, PhD; Adrian L. Rabinowicz, MD; and Enrique Carrazana, MD for the DIAZ.001.05 Study Group. American Academy of Neurology Annual Meeting, Seattle, WA, April 2022.
Safety of a Second Dose of Diazepam Nasal Spray Within 4 Hours in Patients with Seizure Clusters: Final Results From a Long-Term, Phase 3, Open-Label, Repeat-Dose Safety Study. Gregory D. Cascino, MD; Jay Desai, MD2; Daniel Tarquinio, DO; James W. Wheless, MD; R. Edward Hogan, MD; Michael R. Sperling, MD; Kore Liow, MD; Sunita N. Misra, MD, PhD; Enrique Carrazana, MD; and Adrian L. Rabinowicz, MD for the DIAZ.011.05 Study Group. American Academy of Neurology Annual Meeting, Seattle, WA, April 2022.
2021 Alzheimer’s Association International Conference, Denver, CO, Wednesday July 26th
Safety Profile of Valtoco® (diazepam nasal spray) in Patients with Epilepsy: Final Results From a Phase 3, Open-Label, 12-Month Repeat Dose Safety Study. Wheless JW, Sperling MR, Liow K, Vazquez B, Segal EB, Miller I, Hogan RE, Tarquinio D, Mauney W, DeSai J, Dlugos D, Biton V, Cascino G, Carrazana E; Rabinowicz AL, for the DIAZ.001.05 Study Group. American Managed Care Pharmacist (AMCP) Annual Meeting, Virtual. April 2021
Time to Second Doses in Emergency Seizure Patients Treated with Valtoco® (diazepam nasal spray) Across 24 Hours: Subgroup Results From a Completed Phase 3, Open-label, Repeat Dose Safety Study. Wheless JW, Sperling MR, Liow K, Vazquez B, Segal EB, Miller I, Hogan RE, Tarquinio D, Mauney W, DeSai J, Dlugos D, Biton V, Cascino G, Carrazana E; Rabinowicz AL, for the DIAZ.001.05 Study Group. American Managed Care Pharmacist (AMCP) Annual Meeting, Virtual. April 2021
Evaluation of Diazepam Nasal Spray in Patients with Epilepsy Concomitantly Using Maintenance Benzodiazepines: Interim Analysis from a Phase 3, Long-term, Open-label Safety Study. Segal E, Tarquinio D, Miller I, Wheless J, Dlugos D, Biton V, Cascino G, Desai J, Hogan E, Liow K, Mauney W, Sperling M, Cook D, Rabinowicz A, Carrazana E, for the DIAZ.001.05 Study Group. American Academy of Neurology (AAN), Annual Meeting, Virtual. April 2021
Safety Profile of Valtoco® (diazepam nasal spray) in Patients With Epilepsy: Final Results From a Phase 3, Open-Label, 12-Month Repeat Dose Safety Study. Wheless JW, Sperling MR, Liow K, Vazquez B, Segal EB, Miller I, Hogan RE, Tarquinio D, Mauney W, DeSai J, Dlugos D, Biton V, Cascino G, Carrazana E; Rabinowicz AL, for the DIAZ.001.05 Study Group. American Academy of Neurology (AAN), Annual Meeting, Virtual. April 2021
Time to Second Doses in Emergency Seizure Patients Treated with Valtoco® (diazepam nasal spray) Across 24 Hours: Subgroup Results From a Completed Phase 3, Open-label, Repeat Dose Safety Study. Wheless JW, Sperling MR, Liow K, Vazquez B, Segal EB, Miller I, Hogan RE, Tarquinio D, Mauney W, DeSai J, Dlugos D, Biton V, Cascino G, Carrazana E; Rabinowicz AL, for the DIAZ.001.05 Study Group. American Academy of Neurology (AAN), Annual Meeting, Virtual. April 2021
Use of a Second Dose of Diazepam Nasal Spray Within 4 Hours and Effect on the Safety Profile in Patients with Seizure Clusters: Interim Results from a Phase 3, Open-Label, 12-Month Repeat Dose Safety Study. Daniel Tarquinio, Eric B. Segal, Ian Miller, James W. Wheless, R. Edward Hogan, Victor Biton, Gregory D. Cascino, Michael R. Sperling, Kore Liow, Blanca Vazquez, Ricardo Ayala, Weldon Mauney, Jay Desai, Adrian L. Rabinowicz, Enrique Carrazana, for the DIAZ.001.05 Study Group. 74th Annual Meeting of the American Epilepsy Society Meeting, Seattle, WA, Dec 2020.
Evaluation of Diazepam Nasal Spray in Patients with Epilepsy Concomitantly Using Maintenance Benzodiazepines: Interim Analysis from a Phase 3, Long-term, Open-label Safety Study. Eric B. Segal, ; Daniel Tarquinio, Ian Miller, James W. Wheless, Dennis Dlugos, Ricardo Ayala,Victor Biton, Gregory D. Cascino, Jay Desai, R. Edward Hogan, Kore Liow, Weldon Mauney, Michael R. Sperling, Blanca Vazquez, David F. Cook, Adrian L. Rabinowicz, Enrique Carrazana for the DIAZ.001.05 Study Group. 74th Annual Meeting of the American Epilepsy Society Meeting, Seattle, WA, Dec 2020.
Efficacy and Safety Of Adjunctive Padsevonil In Adults With Drug-Resistant Focal Seizures: A Double-Blind, Randomized, Placebo-Controlled Dose-Finding Trial. Rademacher M, Toledo M, Van Paesschen W, Liow K, Esch M, Webster E, Wang N, Werhahn K, French J. 74th Annual Meeting of the American Epilepsy Society Meeting, Seattle, WA, Dec 2020.
Vagal Nerve Stimulation (VNS) in genetic developmental epileptic encephalopathies (DEE):
approach in highly specialized centers around the world. Kwan P, Verner R, O’Brien T, El Tahry R, Keough K, Boggs J, Fahoum F, Greco T, Van Grunderbeek W, Sen A,Core-VNS Study Group. 2020 74th Annual Meeting of the American Epilepsy Society Meeting, Seattle, WA, Dec 2020.
CORE-VNS: A Prospective Outcomes Registry of Patients With Drug-resistant Epilepsy Treated With Vagus Nerve Stimulation Therapy. Kwan P, Verner R, O’Brien T, El Tahry R, Keough K, Boggs J, Fahoum F, Greco T, Van Grunderbeek W, Sen A,Core-VNS Study Group. 2020 74th Annual Meeting of the American Epilepsy Society Meeting, Seattle, WA, Dec 2020.
A Randomized Phase 3 Study in Mild Alzheimer’s Disease (DAYBREAK-ALZ). Sims JR, Zimmer J, Wessels A, Selzler K, Andersen SW, Landry J, Mullen J, Barker P, Stern R, Vellas B, Boada M, Cohen S, MacSweeny E, Tariot P. Lanabecestat. 14th International Conference on Alzheimer’s and Parkinson’s Disease (ADPD) 2019.
Willis B, James D, Scott S, Bragg S, Mullen J, Downing A, Selzler K, Wessels A, Zimmer J, Sims J. Lanabecestat: Biomarker results from two Phase 3 studies in Alzheimer’s disease. 14th International Conference on Alzheimer’s and Parkinson’s Disease (ADPD) 2019.
Mintun M, Shcherbinin S, Charil A, Zimmer J, Andersen S, Landry J, Mullen J, Wessels A, Bragg S, Selzler K, Fleisher A, Sims J. Lanabecestat: Neuroimaging results from two Phase 3 studies in Alzheimer’s disease. 14th International Conference on Alzheimer’s and Parkinson’s Disease (ADPD) 2019.
Two-Part, Double-Blind, Placebo-Controlled, Inpatient, Dose-Ranging Efficacy Study of Staccato Alprazolam (STAP-001) in Patients with Epilepsy with a Predictable Seizure Pattern: Results from the Initial Open-Label Feasibility Part. J French, K Liow, B Vazquez, P Klein, D Tarquinio, B Reich, R Small, J Isojarvi. American Academy of Neurology Annual Meeting, Philadelphia, PA April, 2019
Pharmacokinetics of Diazepam Buccal Film in Adult Patients with Epilepsy: Comparison of Bioavailability with Periictal and Interictal Administration. American Society of Experimental Therapeutics, Bethesda, MD, March 2019.
Pharmacokinetics of Diazepam Buccal Soluble Film in Adult Patients with Epilepsy. American Epilepsy Society Meeting, New Orleans, LA. December 2018.
The Usability of Diazepam Buccal Soluble Film (DBSF) As an Oral Treatment for The Management of Acute Bouts of Cluster Seizures In Adult Patients With Epilepsy. American Epilepsy Society Meeting, New Orleans, LA. December 2018.
Inhaled Levodopa (CVT-301, 84-mg Dose) Significantly Improves Motor Function During OFF Periods in Parkinson’s Disease Subjects: A Phase 3 Study (SPAN-PD). 24th International Congress of Parkinson’s Disease and Movement Disorders, Vancouver, BC, CANADA. 2018
Hawaii Pacific Neuroscience is recognized nationally for our work in neuroscience research conducted at the Clinical Research Center and BRITL (Brain Research, Innovation & Translation Labs). HPN’s robust clinical and academic research programs fosters a culture of innovation and collaboration. Our faculty, residents and students work together whether working within Hawaii or in collaboration with other institutions around the US and international partners and collaborating institutions are published in PubMed indexed journals.
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