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Clinical Research Center

Hawaii Pacific Neuroscience Clinical Research Center (CRC) proven model, and combined years of experience affords us the ability to provide Hawaii patients with groundbreaking new neuroscience treatment options.

Our team fosters a culture of innovation and collaboration whether it is our scientists & students working in the lab to understand disease process or our physician investigators involved in translational research bringing basic science first in human research to our patients in our overnight PK research unit, collaborating with our partners on trial conception, design and IND application to FDA or simply mentoring students, our focus, commitment, and our hearts will always be to our serve our patients and their precious ohana (families) and to improve their quality of life.  

Our Center for Neuroscience Diversity is dedicated to reducing the disparity in minority participation in clinical trials especially for Native Hawaiians and Pacific Islanders and other minority groups as defined by NIH National Institute on Minority Health & Health Disparities (NIMHD)

  • Native Hawaiians and Pacific islanders (20% of Hawaii’s population)
  • Asian Americans (40% of Hawaii’s population and 7% of US) 
  • Underserved rural population (94% Hawaii’s landmass)


The Brain Research, Innovation & Translation Lab (BRITL) is part of the University of Hawaii John Burns School of Medicine MD5 MED 599 Neuroscience Research Course.  BRITL program award scholarships to exceptional medical students each year as well as mentor graduate, undergraduate and medical students working in groups including interns in the Summer Internship Program.  Our faculty lecture for the University of Hawaii Graduate Course BIOMED 640 – Introduction to Clinical Research.  See their Recent Publications 

The Clinical Research Center (CRC) is comprised of the below dedicated research units focused on specific disease entities, fully staffed with full time investigators and credentialed, experienced and qualified raters, research coordinators & staff. The CRC is a nationally highly sought-after site with a reputation for successful completion and recruitment including rapid site start up.  

The CRC has successfully completed over 150 phase I, II, III and IV clinical trials and involved in successful launch of many new therapeutics approved by FDA.   CRC is fully integrated with the Neuroscience Center so that patients seen at disease specific centers of excellence can have easy access to the benefits of world class groundbreaking clinical research at the Clinical Research Center:

Video-EEG Epilepsy Monitoring Unit



  • Central IRB
  • No other ancillary committees or red tapes for Rapid Site Start Up
  • Onsite dedicated Exam rooms
  • Dedicated Monitor rooms
  • Onsite Phase I Normal volunteer Overnight PK Unit
  • Experienced Certified Raters
  • GCP, IATA certified staff
  • Onsite dedicated Neuro IV Infusion Center
  • On-site 3T MRI
  • On-site Radiology Department
  • Onsite Spinal Tap/Fluoroscopic LP
  • Onsite Biomarker (CSF, serum, genetic) sampling
  • Onsite Pharmacy
  • Onsite Emergency resuscitation equipment
  • Use Central Laboratories or

Accredited Local Laboratory

  • Refrigerated, ambient temperature centrifuge.
  • Refrigerators -20C freezer, -80 Freezer
  • Onsite ABRET accredited & CliniLab certified EEG & VEEG Labs
  • Onsite AASM Accredited & CliniLab certified Sleep Laboratory
  • Onsite EMG, EEG
  • Locked/secure Drug storage temperature controlled monitored daily
  • Certified calibrated equipments

Meet Our

Multidisciplinary Team

Kore Kai Liow, M.D., F.A.C.P., F.A.A.N.

Neuroscience Chair

Director, Memory Disorders Center, Comprehensive Epilepsy Center, Neuro COVID Clinic, Center for Neuromodulation, Hawaii Pacific Neuroscience
Principal Investigator, Clinical Research Center, BRITL (Brain Research, Innovation & Translation Labs) BCI (Brain Computer Interface) & Brain Mapping Lab
Clinical Professor of Medicine (Neurology), Graduate Faculty, Clinical & Translational Research, University of Hawai`i John A. Burns School of Medicine

Nicholas Anderson, MD

Sleep Medicine

Director, Sleep and Insomnia Center
Clinical Assistant Professor of Family Medicine,
University of Hawai`i John Burns School of Medicine

Darren DuGas, M.D.


Director, Video-EEG Epilepsy Monitoring Unit (EMU)
Co-Director, Comprehensive Epilepsy Center
Sub- Investigator, Epilepsy Research Unit

Natalia Gonzalez Caldito, M.D.


Director, MS & Neuroimmunology Center
Director, ALS & Neuromuscular Center & IV Infusion Center
Sub investigator, MS & Neuroimmunology & Neuromuscular Research Unit

Eonjung Angeline Kim, M.D.


Director, Headache & Facial Pain Center
Sub- Investigator, Headache Research Unit

Janette Abramowitz, M.D.


Research Faculty, Brain Mapping Lab, Brain Research, Innovation & Translation Labs
Residency: Combined Neurology & Psychiatry University of Massachusetts Medical School Medical School: University of Massachusetts Medical School

Alexander Takayesu, M.D., M.P.H.


Périnatal Psychiatry, Post Partum Dépression
Assistant Professor of Psychiatry, University of Hawaii John A Burns School of Medicine
SubInvestigator, Center for Psychiatric Neuroscience

Paul Smith, M.D.

Lifestyle Medicine

Director, Self Care & Wellness Center
Sub-investigator, Clinical Research Center
Clinical Assistant Professor of Medicine (Neurology), University of Hawai`i John A. Burns School of Medicine

Chris Larrinaga, ARPN-BC, MSN, CNRN

Neurology, Neuroscience

Sleep Medicine
Sub-Investigator, Clinical Research Center

Nicole Evans, PA-C

Neurology, Neuroscience

Sub-Investigator, Clinical Research Center


Neurology, Neuroscience

Memory Disorders
Sub-Investigator, Clinical Research Center

Qing X. Li PhD

Basic Science, Neuroscience

Professor, Department of Molecular Biosciences and Bioengineering, College of Tropical Agriculture and Human Resources University of Hawai‘i at Mānoa, Honolulu

For more

contact the research hotline at (808) 564-6141 or email: Info@HawaiiNeuroscience.com

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