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Clinical Research Center
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Clinical Trials

MISSION of clinical trials conducted at Clinical Research Center in Hawaii is:

  • To provide options to patients who suffers from chronic & sometimes incurable neurological conditions
  • For those whose conditions are not satisfactory controlled on approved therapies
  • For those in Hawaii who cannot travel to the mainland for advanced, innovative or research treatments

Our HOPE is that it can meet an unmet need for

  • Patients and their precious families in Hawaii who needs to have options and find hope
  • Hawaii’s physicians who want to incorporate research options as part of their comprehensive approach
  • Promote local awareness, education on condition and empower patients, families & caretakers

Research Therapies are FREE to qualified patients and some may also offer FREE neighbor island travel ALL patients continue to follow up with their primary neurologists & primary care physicians while in trial

Conditions Indications Study Name Treatment/MOA NIH Website Who Qualifies
Alzheimer’s Memory MCI, Mild Mod AD
PRESENCE ADPO LY3154207 (Mevidalen) D1 ReceptorsNCT06538116 MMSE 13-24
Alzheimer’s MemoryMCI, Mild ADBRAINSHUTTLEIV RO7126209 (Trontinemab)NCT04639050 MMSE 22-30
Alzheimer’s Memory
MCI, Mild ADPO Buntanetap (Neuroprotective)
MMSE 21-28
Alzheimer’s Memory
MCI, Mild ADIV VHB937 (TREM2 Activator)CDR 0.5-1
Alzheimer’s MemoryAD, AgitationPO NMRA-323511 V1a ReceptorNCT06546995MMSE 5-24
Parkinson’s Early PDLUMA PO BIIB1222 - LRRK2 - DMTNCT05348785PD within 2 years
Parkinson’sPD with Motor FluctuationsPO Lu AF28996 – D1 D2 AgonistNCT04291859> 1.5 hr OFF
Epilepsy Focal SeizureRISE 2PO BHV-7000 VG Potassium channelNCT06132893> 4 seizures/month
Epilepsy Focal SeizureX-TOLE2PO XEN1101 Novel Potassium channelNCT05614063> 4 seizures/month
EpilepsyPrimary GeneralizedX-TOLE3PO XEN1101 Novel Potassium channelNCT056671423 PGTC in 8 weeks
EpilepsyFocal or GeneralizedSTARSInhaled Abortive EP0162 Staccato AlprazolamNCT05077904Seizures
MS Neuroimmunology RRMS IV ABP 692 vs OcrevusEDSS ≤ 5.5
≥ 2 relapse ≤ 2 years
NeuromuscularCIDPHYbISCUEIV HyQviaNCT06538064CIDP 2021 Guidelines
NeuromuscularMyasthenia GravisAPPRAISEPO LNP023 (Iptacopan)NCT06517758MGFA Class II-IV
NeuromuscularSpasticityDIRECTIONIM Dysport Abobotulinumtoxin ANCT04936542Spasticity > 3 mths
PainMigrainePIONEERPO LAHV/LAHW/LasmiditanNCT04396236Migraine > 6 mths
PainMigraine MenstrualMOSAICPO UbrogepantMigraine > 12 months
2 out of 3 are menstrual
Psychiatric NeuroPost Partum DépressionRECONNECTSQ RE 104NCT06342310DSM5 Post PD
Psychiatric NeuroAdjustment Disorder in ALS, MS, Parkinson’sADCOSQ RE 104AjD > 4 weeks
Rare Neuro DiseasesDentatorubral-Pallidoluysian Atrophy Intrathecal nL-ATN-002 ASO TherapyFDA IND 173123-Open label single center single patient

Kore Kai Liow, MD, FACP, FAAN

Principal Investigator, Clinical Research Center
Hawaii Pacific Neuroscience
Clinical Professor, Dept. of Medicine (Neurology),
Graduate Faculty, Clinical & Translational Research
University of Hawai`i John Burns School of Medicine

Meet Our

Multidisciplinary Team

Kore Kai Liow, M.D., F.A.C.P., F.A.A.N.

Neurology
Neuroscience Chair

Director, Memory Disorders Center, Comprehensive Epilepsy Center, Neuro COVID Clinic, Center for Neuromodulation, Hawaii Pacific Neuroscience
Principal Investigator, Clinical Research Center, BRITL (Brain Research, Innovation & Translation Labs) BCI (Brain Computer Interface) & Brain Mapping Lab
Clinical Professor of Medicine (Neurology), Graduate Faculty, Clinical & Translational Research, University of Hawai`i John A. Burns School of Medicine

Nicholas Anderson, MD

Sleep Medicine

Director, Sleep and Insomnia Center
Clinical Assistant Professor of Family Medicine,
University of Hawai`i John Burns School of Medicine

Darren DuGas, M.D.

Neurology

Director, Video-EEG Epilepsy Monitoring Unit (EMU)
Co-Director, Comprehensive Epilepsy Center
Sub- Investigator, Epilepsy Research Unit

Natalia Gonzalez Caldito, M.D.

Neurology

Director, MS & Neuroimmunology Center
Director, ALS & Neuromuscular Center & IV Infusion Center
Sub investigator, MS & Neuroimmunology & Neuromuscular Research Unit

Eonjung Angeline Kim, M.D.

Neurology

Director, Headache & Facial Pain Center
Sub- Investigator, Headache Research Unit

Janette Abramowitz, M.D.

Neurology

Research Faculty, Brain Mapping Lab, Brain Research, Innovation & Translation Labs
Residency: Combined Neurology & Psychiatry University of Massachusetts Medical School Medical School: University of Massachusetts Medical School

Alexander Takayesu, M.D., M.P.H.

Psychiatry

Perinatal Psychiatry, Post Partum Depression
Assistant Professor of Psychiatry, University of Hawaii John A Burns School of Medicine
SubInvestigator, Center for Psychiatric Neuroscience

Paul Smith, M.D.

Lifestyle Medicine

Director, Self Care & Wellness Center
Sub-investigator, Clinical Research Center
Clinical Assistant Professor of Medicine (Neurology), University of Hawai`i John A. Burns School of Medicine

Chris Larrinaga, APRN-BC, MSN, CNRN

Neurology, Neuroscience

Sleep Medicine
Sub-Investigator, Clinical Research Center

Nicole Evans, PA-C

Neurology, Neuroscience

Sub-Investigator, Clinical Research Center

Qi Zhi, DNP, MPH, FNP-BC

Neurology, Neuroscience

Memory Disorders
Sub-Investigator, Clinical Research Center

Qing X. Li PhD

Basic Science, Neuroscience

Professor, Department of Molecular Biosciences and Bioengineering, College of Tropical Agriculture and Human Resources University of Hawai‘i at Mānoa, Honolulu

Katy Tarrit, Ph.D.

Information and Computer Sciences, AI (Artificial Intelligence)
NeuroAI Research Lab/Alzheimer's Neural Network EEG (ANNE) Lab

Assistant Professor, Katy Tarrit, Ph.D.
Assistant Professor, Information and Computer Sciences
University of Hawai'i at Manoa

Honolulu

West Oahu

RECENT BLOGS

HPN Office Hours

Monday : 08.30 - 12.30 1.30 - 4.30
Tuesday : 08.30 - 12.30 1.30 - 4.30
Wednesday : 08.30 - 12.30 1.30 - 4.30
Thursday : 08.30 - 12.30 1.30 - 4.30
Friday : 08.30 - 12.30 1.30 - 4.30
Saturday : 08.30 - 12.30 1.30 - 4.30

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+1 (808) 261-4476

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