| Conditions | Indications | Study Name | Treatment/MOA | NIH Website | Who Qualifies |
|---|---|---|---|---|---|
| Alzheimer’s Memory | MCI Mild AD | CELIA | IT BIIB080 -Tau Targeting ASO Gene Therapy | NCT05399888 | MMSE > 22 |
| Alzheimer’s Memory | MCI, Mild Mod AD | ASCENT | SQ PRX012 – Next Generation Anti Amyloid (Must be willing to travel to partner Amyloid PET facility in LA) | Ascent Trial Info | MMSE >18 |
| Alzheimer’s Memory | MCI, Mild Mod AD | PO CVL-231 | MMSE 8-26 | ||
| Alzheimer’s Memory | MCI, Mild Mod AD | PRESENCE | PO Mevidalen | MMSE 13-24 | |
| Parkinson’s | Early PD | LUMA | PO BIIB1222 - LRRK2 Lysosomal Activities | NCT05348785 | PD within 2 years |
| Parkinson’s | PD with Motor Flucations | PO Lu AF28996 – D1 D2 Agonist | NCT04291859 | > 1.5 hr OFF | |
| Epilepsy | Focal Seizure | RISE 2 | PO BHV-7000 VG Potassium channel | NCT06132893 | > 4 seizures/month |
| Epilepsy | Focal Seizure | X-TOLE2 | PO XEN1101 Novel Potassium channel | NCT05614063 | > 4 seizures/month |
| Epilepsy | Primary Generalized | X-TOLE3 | PO XEN1101 Novel Potassium channel | NCT05667142 | 3 PGTC in 8 weeks |
| Abortive | Focal or Generalized | STARS | Inhaled EP0162 Staccato Alprazolam | NCT05077904 | Seizures |
| MS Neuroimmunology | RRMS | IV ABP 692 (More information to come) | |||
| Neuromuscular | CIDP | IV HyQvia (More information to come) | |||
| Neuromuscular | Myasthenia Gravis | PO Iptacopan(More information to come) | AChR+ antibody | ||
| Neuromuscular | Spasticity | DIRECTION | IM Dysport Abobotulinumtoxin A | NCT04936542 | Spasticity > 3 mths |
| Pain Migraine | PIONEER | PO LAHV/LAHW/Lasmiditan | NCT04396236 | Migraine > 6 mths | |
| Psychiatric Neuro | Post Partum Dépression | RECONNECT | SQ RE 104 | NCT06342310 | DSM5 PostPD |
| Rare Neuro Diseases | Huntington’s Chorea | DIMENSION | PO SAGE-718- NMDA PAM | NCT05107128 | CAG Mutation > 40U |
| Rare Neuro Diseases | Multiple System Atrophy | CYPRESS | PO TD-9855 Ampreloxetine NeRI | NCT05696717 | Neurogenic Orthostatic > SBP or > 10 DBP |
Principal Investigator, Clinical Research Center Hawaii Pacific Neuroscience Clinical Professor, Dept. of Medicine (Neurology), Graduate Faculty, Clinical & Translational Research University of Hawai`i John Burns School of Medicine
Neurology
Neuroscience Chair
Director, Memory Disorders Center, Comprehensive Epilepsy Center, Neuro COVID Clinic, Center for Neuromodulation, Hawaii Pacific Neuroscience
Principal Investigator, Clinical Research Center, BRITL (Brain Research, Innovation & Translation Labs) BCI (Brain Computer Interface) & Brain Mapping Lab
Clinical Professor of Medicine (Neurology), Graduate Faculty, Clinical & Translational Research, University of Hawai`i John A. Burns School of Medicine
