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Clinical Trials

MISSION of clinical trials conducted at Clinical Research Center in Hawaii is:

  • To provide options to patients who suffers from chronic & sometimes incurable neurological conditions
  • For those whose conditions are not satisfactory controlled on approved therapies
  • For those in Hawaii who cannot travel to the mainland for advanced, innovative or research treatments

Our HOPE is that it can meet an unmet need for

  • Patients and their precious families in Hawaii who needs to have options and find hope
  • Hawaii’s physicians who want to incorporate research options as part of their comprehensive approach
  • Promote local awareness, education on condition and empower patients, families & caretakers

Research Therapies are FREE to qualified patients and some may also offer FREE neighbor island travel ALL patients continue to follow up with their primary neurologists & primary care physicians while in trial

Conditions Indications Study Name Treatment NIH Website Who Qualifies
Alzheimer’s Memory Mild Moderate AD LIFT (Neuro Synaptic) Fosgonimeton NCT04488419 MMSE 14-24
Alzheimer’s MemoryMild Moderate AD (Axonal Transport) Buntanetap NCT05686044 MMSE 14-24
Alzheimer’s MemoryMCI Mild AD ENVISION (Amyloid0 Aducanumab NCT05310071 MMSE > 22
Alzheimer’s MemoryMCI Mild AD CELIA (Tau ASO) BIIB080 NCT05399888 MMSE > 22
Alzheimer’s MemoryMCI Mild AD LIGHTWAVE (NMDA) SAGE-718 NCT05619692 MoCA 15-25/MMSE > 22
Parkinson’s Early PD LUMA (LRRK2) BIIB1222 NCT05348785 PD within 2 years
Parkinson’sEarly PD (Axonal Transport) Buntanetap NCT05357989 H&Y 1-3 On state
Parkinson’sTremor (Calcium) Suvecaltamide NCT05122650 Moderate to Severe PD Tremor
Essential Tremor EVEREST (Calcium) Suvecaltamide NCT05122650 Moderate to Severe Tremor
Epilepsy Focal REALIZE CVL-865 NCT04244175 > 4 seizures/month
EpilepsyFocal X-TOLE2XEN1101 NCT05614063 Seizures > 2 years
EpilepsyPGTC X-TOLE3XEN1101 NCT05667142 3 PGTC in 8 weeks
Abortive Focal or Generalized STARSEP0162 or 0165 NCT05077904 Seizures
Spasticity DIRETION Dysport NCT04936542 Upper limb Spasticity > 3 mths
Headache Migraine LAHV/LAHW Lasmiditan NCT04396236 Migraine > 6 mths
Huntington’s Chorea DIMENSION SAGE-718 NCT04396236 CAG Mutation > 40U
Multiple System Atrophy CYPRESS Ampreloxetine NCT05696717 Neurogenic Orthostatic > SBP or > 10 DBP

Kore Kai Liow, MD, FACP, FAAN

Principal Investigator, Clinical Research Center
Hawaii Pacific Neuroscience
Clinical Professor, Dept. of Medicine (Neurology),
Graduate Faculty, Clinical & Translational Research
University of Hawai`i John Burns School of Medicine

Honolulu

West Oahu

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Monday : 08.30 - 12.30 1.30 - 4.30
Tuesday : 08.30 - 12.30 1.30 - 4.30
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Friday : 08.30 - 12.30 1.30 - 4.30
Saturday : 08.30 - 12.30 1.30 - 4.30

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+1 (808) 261-4476

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