Alzheimer's Neural Network EEG Research Laboratory

Hawai‘i Memory Disorders Center &
Alzheimer’s Research Unit

2024 ANNE Research Team

(front) medical students Michael Read, janette Keola, Kirra Borrelo, Nathan Kim Neurologist Kore Kai Liow, MD, Shay Nakahira, Kaylie Yamauchi, Sarah Hogue, Research staffs (back row) Kelly Asahi, Jason Edwards, Sam Kim, John Seib, Qi Zhi, DNP, MPH, Ena Zhu

ANNE (Alzheimer’s Neural Network EEG) Lab joins Mass General & UCSD as Early Adopters to Harness AI’s Power to Pioneer Use of EEG in Early Detection and Monitoring of Alzheimer’s Disease

There is currently no widely available tool to measure someone’s memory or cognitive abilities to look for early signs of Alzheimer’s or monitor the efficacy of treatment or progression.  Traditional memory testing are subjective and depends on patients’ performance thus we rely on invasive test like spinal tap and use of radioactive substance injected into body to look for Alzheimer’s biomarker in the brain which are not readily accessible in island communities such as Hawaii state and many rural communities in US.  Lack of readily available testing often leads to delayed diagnosis & intervention and eventually poor long-term outcome.

 

The Hawaii Memory Disorders Center & Alzheimer’s Research Unit collaborates with the Advance Brain Monitoring to launch the Hawaii ANNE (Alzheimer’s Neural Network EEG) Lab dedicated to develop an easily accessible, noninvasive, nontoxic and cost effective tool to measures synaptic neuronal network brain electrical activities using BEAM™ (Biomarker based Electrophysiology Advanced Brain Monitoring). BEAM is a proven EEG platform developed using machine learning AI algorithms to map the progression of cognitive decline across the dementias.

Peer Reviewed Pub Med Publication: Abnormal Temporal Slowing on EEG Findings in Preclinical Alzheimer’s Disease Patients with the ApoE4 Allele: A Pilot Study Kim N, Tan C, Ma E, Kutlu S, Carrazana E, Vimala V, Viereck J, Liow K. (October 28, 2023) Cureus 15(10): e47852. DOI 10.7759/Cureus.47852.

“Our Hawaii patients, caregivers, families, neurologists & researchers are honored to be able to play a role to contribute to this important ground breaking research to develop a noninvasive, widely available and cost effective tool for Alzheimer’s Disease to serve our island and rural populations, ” Kore Kai Liow, MD, Director, Hawaii Memory Disorders Center Principal Investigator, Alzheimer’s Neural Network EEG (ANNE) Research Lab, Clinical Professor of Medicine (Neurology), Graduate Faculty, Clinical & Translational Research, University of Hawai`i John Burns School of Medicine.   Dr. Liow is a research neurologist trained in clinical neurophysiology & EEG at National Institutes of Health (NIH), Bethesda, Maryland.  Info: [email protected]

Nashville, TN, Dec 2022

EEG Predicting Alzheimer’s Disease Onset in Preclinical Patients with the ApoE4 Allele: An Update on EEG Findings

What is BEAM? (Biomarker – Based Electrophysiology for Advanced Monitoring)

BEAM™ is a new test used by neurologist combining EEG with neurocognitive testing.

In addition to routine EEG, you will be asked to perform a series of active and passive visual, auditory tasks to assess attention, memory and emotion. 

Using the latest AI- Machine Learning technology, a set of unique brain “fingerprints” or cognitive biomarkers unique to the patient will be generated in comparison with thousands of normal data to help your doctor to: 

-making accurate diagnosis of your condition

-quantify the severity of the condition

-tracking disease progression

-assessing whether a treatment or intervention has been effective

For more information: https://hawaiineuroscience.com/alzheimer-eeg-project/

https://www.advancedbrainmonitoring.com/applications/biomarkers

Our Hawaii patients, caregivers, families, neurologists & researchers are honored to be able to play a role to contribute to this important ground breaking research to develop a noninvasive, widely available and cost effective tool for Alzheimer’s Disease to serve our island and rural populations, ” Kore Kai Liow, MD, Director, Hawaii Memory Disorders Center Principal Investigator, Alzheimer’s Research Unit, Clinical

Professor of Medicine (Neurology), Graduate Faculty, Clinical & Translational Research, University of Hawai`i John Burns School of Medicine.   Dr. Liow is a research neurologist trained in clinical neurophysiology & EEG at National Institutes of Health (NIH), Bethesda, Maryland.  Info: ANNE Research Lab PI [email protected] 

Meet Our

Multidisciplinary Team

Kore Kai Liow, M.D., F.A.C.P., F.A.A.N.

Neurology
Neuroscience Chair

Director, Memory Disorders Center, Comprehensive Epilepsy Center, Neuro COVID Clinic, Center for Neuromodulation, Hawaii Pacific Neuroscience
Principal Investigator, Clinical Research Center, BRITL (Brain Research, Innovation & Translation Labs) BCI (Brain Computer Interface) & Brain Mapping Lab
Clinical Professor of Medicine (Neurology), Graduate Faculty, Clinical & Translational Research, University of Hawai`i John A. Burns School of Medicine

Nicholas Anderson, MD

Sleep Medicine

Director, Sleep and Insomnia Center
Clinical Assistant Professor of Family Medicine,
University of Hawai`i John Burns School of Medicine

Darren DuGas, M.D.

Neurology

Director, Video-EEG Epilepsy Monitoring Unit (EMU)
Co-Director, Comprehensive Epilepsy Center
Sub- Investigator, Epilepsy Research Unit

Natalia Gonzalez Caldito, M.D.

Neurology

Director, MS & Neuroimmunology Center
Director, ALS & Neuromuscular Center & IV Infusion Center
Sub investigator, MS & Neuroimmunology & Neuromuscular Research Unit

Eonjung Angeline Kim, M.D.

Neurology

Director, Headache & Facial Pain Center
Sub- Investigator, Headache Research Unit

Janette Abramowitz, M.D.

Neurology

Research Faculty, Brain Mapping Lab, Brain Research, Innovation & Translation Labs
Residency: Combined Neurology & Psychiatry University of Massachusetts Medical School Medical School: University of Massachusetts Medical School

Alexander Takayesu, M.D., M.P.H.

Psychiatry

Perinatal Psychiatry, Post Partum Depression
Assistant Professor of Psychiatry, University of Hawaii John A Burns School of Medicine
SubInvestigator, Center for Psychiatric Neuroscience

Paul Smith, M.D.

Lifestyle Medicine

Director, Self Care & Wellness Center
Sub-investigator, Clinical Research Center
Clinical Assistant Professor of Medicine (Neurology), University of Hawai`i John A. Burns School of Medicine

Chris Larrinaga, APRN-BC, MSN, CNRN

Neurology, Neuroscience

Sleep Medicine
Sub-Investigator, Clinical Research Center

Nicole Evans, PA-C

Neurology, Neuroscience

Sub-Investigator, Clinical Research Center

Qi Zhi, DNP, MPH, FNP-BC

Neurology, Neuroscience

Memory Disorders
Sub-Investigator, Clinical Research Center

Qing X. Li PhD

Basic Science, Neuroscience

Professor, Department of Molecular Biosciences and Bioengineering, College of Tropical Agriculture and Human Resources University of Hawai‘i at Mānoa, Honolulu

Katy Tarrit, Ph.D.

Information and Computer Sciences, AI (Artificial Intelligence)
NeuroAI Research Lab/Alzheimer's Neural Network EEG (ANNE) Lab


Assistant Professor, Katy Tarrit, Ph.D.
Assistant Professor, Information and Computer Sciences
University of Hawai'i at Manoa

Call us or text us

(808) 261-4476

Call us or text us at (808) 261-4476
We are available Monday to Friday
8:30 am to 4:30 pm

 

We take a lunch (phones off) from 12:30-1:30pm. Leave a message we will get back to you within 24-48 business hours.

You-or a person you care formay be able to join if you:

• Are from 55 to 90 years old
 
• Have had Alzheimer’s disease for at least 12 months before study screening
 
• Are experiencing agitation, including feeling tense and restless, beginning at least 2 weeks before study screening
 
* Are able to swallow capsules whole
 
• Have a caregiver
 
To join the study, you will need to meet other requirements, which the study team will go over with you.
 
You may be reimbursed for study-related expenses, and support for participants and care partners is offered throughout the study.
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