Josiah Morita,1 Tyler Shimabukuro,2 Maya Matsubara,2 Alyssa Jade Nunez,3 Isabel Casimiro3
1 George Washington University, Washington, DC
2 John A. Burns School of Medicine, University of Hawaiʻi, Honolulu, HI
3 Queens Medical Center, Honolulu, HI
Introduction: Type 2 diabetes (T2D) is a chronic disease characterized by poor blood glucose control and is associated with complications including cardiovascular disease, kidney damage, and neurologic conditions such as Alzheimer’s disease, diabetic neuropathy, and stroke. T2D is especially prevalent in certain racial/ethnic minority groups, including Asians, Native Hawaiians, and other Pacific Islanders, who make up two-thirds of Hawaii’s population. Incretin-based therapies (IBT), including GLP-1 receptor agonists and dual GLP-1/GIP agonists, enhance insulin secretion, suppress glucagon, and promote satiety. This study assessed dietary changes pre- and post-IBT in two patients with T2D and obesity who were successfully weaned off insulin.
Methods: Patients completed 7-day food logs reflecting current and recalled pre-IBT intake. Calories and macronutrients were analyzed using the Nutritionix app.
Results: The average reduction was 9,470 calories and 685g carbohydrates per week. Patient 1 reduced carbohydrate intake by 71% while losing 35.5 pounds. Patient 2 eliminated snacking and alcohol consumption.
Conclusion: IBT appears effective in reducing caloric and carbohydrate intake, supporting weight loss and insulin discontinuation. Further studies are needed in larger population
