A two-year international study highlights the potential benefits of vagus nerve stimulation (VNS) therapy for individuals living with Lennox–Gastaut syndrome (LGS), a rare and severe form of childhood epilepsy. The findings demonstrate that long-term VNS therapy can reduce seizure frequency,…
A peer-reviewed study published in Epilepsia (October 2025) evaluated the pharmacokinetics, safety, and tolerability of single-dose Staccato® alprazolam in adolescents with epilepsy. The findings support appropriate dose selection for adolescents aged 12–17 years, contributing important evidence toward the clinical development…
Hawaii Memory & Alzheimer’s Research has joined leading academic institutions—including UCSF, UC San Diego, and the Cleveland Clinic—in a multicenter clinical trial investigating VHB937, a novel TREM2-stabilizing monoclonal antibody engineered to cross the blood–brain barrier and reduce neuroinflammation in Alzheimer’s…
The Hawaii Parkinson’s & Movement Center and Hawaii Parkinson’s Research Unit have been awarded Hawaiʻi’s first clinical research study focused on Lewy Body Dementia (LBD). This landmark study investigates ACP-204 (remlifanserin), an investigational medication developed to treat hallucinations and delusions…
Researchers at the Hawaii Parkinson’s Disease Center and Hawaii Parkinson’s Research Unit are participating in groundbreaking research evaluating prasinezumab, an investigational monoclonal antibody that may become the first disease-modifying treatment to slow the progression of Parkinson’s disease. This research is…
Accurate detection of mild cognitive impairment (MCI) and Alzheimer’s disease (AD) is critical as therapeutic strategies increasingly emphasize early intervention. While the Mini-Mental State Examination (MMSE) remains a widely used cognitive screening tool, its sensitivity to subtle neurophysiological changes is…
Early and accurate differentiation between Alzheimer’s disease (AD) and mild cognitive impairment (MCI) is increasingly critical as new disease-modifying therapies emphasize intervention at the earliest possible stages. However, MCI often represents a heterogeneous and nonspecific prodromal phase, complicating clinical diagnosis…
The Hawaii Headache & Facial Pain Center and Hawaii Headache Research Unit have been awarded a clinical research study to investigate XEOMIN® (incobotulinumtoxinA) as a potential preventive treatment for chronic and episodic migraine. This important research initiative aims to address…
The American Academy of Neurology (AAN) official continuing medical education journal, Continuum: Lifelong Learning in Neurology®, has referenced research conducted by University of Hawaiʻi John A. Burns School of Medicine (JABSOM) neurologists and former medical students in its June 2025…
The American Academy of Neurology (AAN) official continuing medical education journal, Continuum: Lifelong Learning in Neurology®, has referenced research conducted by University of Hawaiʻi John A. Burns School of Medicine (JABSOM) neurologists and former medical students in its February 2025…